Adv Biomed Res. 2015 Nov 23;4:245. doi: 10.4103/2277-9175.170240. eCollection 2015.

Collagen cross-linking effect on progressive keratoconus in patients younger than 18 years of age: A clinical trial.

Advanced biomedical research

Alireza Peyman, Ali Kamali, Maral Khushabi, Kobra Nasrollahi, Neda Kargar, Maryam Taghaodi, Hasan Razmjoo, Farhad Fazel, Asiyeh Salesi

PMID: 26693470 PMCID: PMC4685639 DOI: 10.4103/2277-9175.170240

Abstract

BACKGROUND: Keratoconus is a bilateral non-inflammatory corneal disease. Collagen cross-linking (CXL) is a new treatment option for the disease that uses ultraviolet A light irradiation and riboflavin administration. The aim of this study is to evaluate the effect of CXL on corneal topographic and refractive values in patients with keratoconus younger than 18 years of age.

MATERIALS AND METHODS: For the clinical trial study, 37 patients (64 eyes) younger than 18 years of age with progressive keratoconus were included. Age, sex, family history of keratoconus, and history of allergic disorders and eye rubbing were recorded. Refractive, topographic, and topometric indices were evaluated before and 12 months after the CXL with 3mW for 30 minutes.

RESULTS: Mean age (±SD) of the patients was 15.83 ± 1.53 years; 26 (70.3%) of the 37 patients were male. Fourteen (37.8%) had positive family history of keratoconus, 11 (29.7%) had history of allergic disorders, and 15 (40.5%) had positive history of eye rubbing. Of the refractive values, cylinder value decreased significantly from -4.50 ± 0.29 to -4.11 ± 0.28 (P = 0.001). Also, the logarithm of minimal angle of resolution (logMAR) uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA) improved significantly 12 months after CXL (P = 0.012 and 0.001, respectively). Maximum keratometry before and after the operation was 53.82 ± 0.72 and 53.33 ± 0.72, respectively (P = 0.018). Differences for simulated K values, the thinnest cornea pachymetry, keratoconus index (KI), index of highest asymmetry (IHA), and index of highest decentration (IHD) before and 12 months after the CXL were statistically significant (P = 0.015, 0.034, <0.001, 0.017, 0.019, and 0.004, respectively).

CONCLUSION: CXL improves the refractory, topographic, and topometric indices in patients with keratoconus younger than 18 years of age.

Keywords: Collagen cross-linking; progressive keratoconus; refractive value; topography

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