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Tanner JJ. SAXS fingerprints of aldehyde dehydrogenase oligomers. Data Brief. 2015;5:745-51doi: 10.1016/j.dib.2015.10.017.
Tanner, J. J. (2015). SAXS fingerprints of aldehyde dehydrogenase oligomers. Data in brief, 5745-51. https://doi.org/10.1016/j.dib.2015.10.017
Tanner, John J. "SAXS fingerprints of aldehyde dehydrogenase oligomers." Data in brief vol. 5 (2015): 745-51. doi: https://doi.org/10.1016/j.dib.2015.10.017
Tanner JJ. SAXS fingerprints of aldehyde dehydrogenase oligomers. Data Brief. 2015 Oct 25;5:745-51. doi: 10.1016/j.dib.2015.10.017. eCollection 2015 Dec. PMID: 26693506; PMCID: PMC4659792.
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Data Brief. 2015 Oct 25;5:745-51. doi: 10.1016/j.dib.2015.10.017. eCollection 2015 Dec.

SAXS fingerprints of aldehyde dehydrogenase oligomers.

Data in brief

John J Tanner

Affiliations

  1. Departments of Biochemistry and Chemistry, University of Missouri-Columbia, Columbia, MO 65211, United States.

PMID: 26693506 PMCID: PMC4659792 DOI: 10.1016/j.dib.2015.10.017

Abstract

Enzymes of the aldehyde dehydrogenase (ALDH) superfamily catalyze the nicotinamide adenine dinucleotide-dependent oxidation of aldehydes to carboxylic acids. ALDHs are important in detoxification of aldehydes, amino acid metabolism, embryogenesis and development, neurotransmission, oxidative stress, and cancer. Mutations in genes encoding ALDHs cause metabolic disorders, including alcohol flush reaction (ALDH2), Sjögren-Larsson syndrome (ALDH3A2), hyperprolinemia type II (ALDH4A1), γ-hydroxybutyric aciduria (ALDH5A1), methylmalonic aciduria (ALDH6A1), pyridoxine dependent epilepsy (ALDH7A1), and hyperammonemia (ALDH18A1). We previously reported crystal structures and small-angle X-ray scattering (SAXS) analyses of ALDHs exhibiting dimeric, tetrameric, and hexameric oligomeric states (Luo et al., Biochemistry 54 (2015) 5513-5522; Luo et al., J. Mol. Biol. 425 (2013) 3106-3120). Herein I provide the SAXS curves, radii of gyration, and distance distribution functions for the three types of ALDH oligomer. The SAXS curves and associated analysis provide diagnostic fingerprints that allow rapid identification of the type of ALDH oligomer that is present in solution. The data sets provided here serve as a benchmark for characterizing oligomerization of ALDHs.

Keywords: Aldehyde dehydrogenase; Protein oligomeric state; Small-angle X-ray scattering; X-ray crystallography

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