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Sosa AM, Amaya S, Salamanca Capusiri E, et al. Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis. Nat Prod Res. 2016;30(22):2611-2615doi: 10.1080/14786419.2015.1126260.
Sosa, A. M., Amaya, S., Salamanca Capusiri, E., Gilabert, M., Bardón, A., Giménez, A., Vera, N. R., & Borkosky, S. A. (2016). Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis. Natural product research, 30(22), 2611-2615. https://doi.org/10.1080/14786419.2015.1126260
Sosa, Andrea M, et al. "Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis." Natural product research vol. 30,22 (2016): 2611-2615. doi: https://doi.org/10.1080/14786419.2015.1126260
Sosa AM, Amaya S, Salamanca Capusiri E, Gilabert M, Bardón A, Giménez A, Vera NR, Borkosky SA. Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis. Nat Prod Res. 2016 Nov;30(22):2611-2615. doi: 10.1080/14786419.2015.1126260. Epub 2016 Jan 12. PMID: 26755152.
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Nat Prod Res. 2016 Nov;30(22):2611-2615. doi: 10.1080/14786419.2015.1126260. Epub 2016 Jan 12.

Active sesquiterpene lactones against Leishmania amazonensis and Leishmania braziliensis.

Natural product research

Andrea M Sosa, Susana Amaya, Efrain Salamanca Capusiri, Miguel Gilabert, Alicia Bardón, Alberto Giménez, Nancy R Vera, Susana A Borkosky

Affiliations

  1. a Facultad de Bioquímica, Química y Farmacia , Universidad Nacional de Tucumán , Tucumán , Argentina.
  2. b Facultad de Ciencias Exactas y Naturales , Universidad Nacional de Catamarca , Catamarca , Argentina.
  3. c Instituto de Investigaciones Fármaco Bioquímicas , Universidad Mayor de San Andrés , La Paz , Bolivia.
  4. d Instituto de Química del Noroeste Argentino - Consejo Nacional de Investigaciones Científicas y Técnicas (INQUINOA-CONICET) , Tucumán , Argentina.

PMID: 26755152 DOI: 10.1080/14786419.2015.1126260

Abstract

Seventeen sesquiterpene lactones (SLs) isolated from five species of the tribe Vernonieae were evaluated for their in vitro activity against promastigotes of Leishmania amazonensis and Leishmania braziliensis. Additionally, a quantitative structure activity relationship has been made, since all these natural compounds were found to have potent to mild antileishmanial properties. The most active compounds against L. braziliensis were 16 and 17 (IC

Keywords: Leishmania amazonensis; Leishmania braziliensis; Vernonieae; antileishmanial activity; sesquiterpene lactones

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