Radiat Oncol J. 2015 Dec;33(4):310-9. doi: 10.3857/roj.2015.33.4.310. Epub 2015 Dec 30.

Radiotherapy as an effective treatment modality for follicular lymphoma: a single institution experience.

Radiation oncology journal

Seo Hee Choi, Jaeho Cho, Jin Seok Kim, June-Won Cheong, Chang-Ok Suh

PMID: 26756031 PMCID: PMC4707214 DOI: 10.3857/roj.2015.33.4.310

Abstract

PURPOSE: Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma that is highly sensitive to radiotherapy (RT). However, the effectiveness of RT has not been well established. We reviewed our experiences to assess the role of RT for FL and analyze treatment results.

MATERIALS AND METHODS: Retrospective analysis was done on 29 patients who received first RT between January 2003 and August 2013. Of 23 early stage (stage I, II) patients, 16 received RT alone, four received chemotherapy followed by RT, two received RT postoperatively, and one received salvage RT for relapse after resection. Six advanced-stage (stage III, IV) patients received RT after chemotherapy: two received consolidation RT, three received salvage RT for residual lesions, and one received RT for progressive sites. Median RT dose was 30.6 Gy (range, 21.6 to 48.6 Gy). Median follow-up duration was 62 months (range, 6 to 141 months).

RESULTS: All patients showed complete response in the radiation field. Eight outfield relapses were reported. Seven patients received salvage treatment (three chemotherapy, four RT). Four patients showed excellent responses, especially to RT. Estimated 5-year and 10-year relapse-free survivals were 72% and 60%. In the RT-alone group, 5-year relapse-free survival was 74.5%. All advanced-stage patients were disease-free with 100% 5-year overall survival. Disease-specific death was noted in only one patient; four others died of other unrelated causes. No significant toxicity was reported.

CONCLUSION: RT resulted in excellent treatment outcomes for all FL stages when used as a primary treatment modality for early stage or salvage-treatment modality for advanced-stage disease.

Keywords: Follicular lymphoma; Radiotherapy; Treatment outcome

References

1. J Clin Oncol. 2012 Sep 20;30(27):3368-75 - PubMed
2. Blood. 2000 Feb 1;95(3):783-9 - PubMed
3. Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):316-20 - PubMed
4. Blood. 2014 May 8;123(19):2944-52 - PubMed
5. Blood. 2005 Feb 15;105(4):1417-23 - PubMed
6. Strahlenther Onkol. 2001 Nov;177(11):597-603 - PubMed
7. Blood. 2004 Sep 1;104(5):1258-65 - PubMed
8. Lancet Oncol. 2014 Apr;15(4):457-63 - PubMed
9. Int J Radiat Oncol Biol Phys. 2013 May 1;86(1):121-7 - PubMed
10. J Clin Oncol. 2008 Oct 1;26(28):4579-86 - PubMed
11. Int J Radiat Oncol Biol Phys. 1997 Apr 1;38(1):3-8 - PubMed
12. PLoS One. 2013 Jun 06;8(6):e65156 - PubMed
13. J Clin Oncol. 2013 Apr 20;31(12):1506-13 - PubMed
14. Ann Oncol. 2013 Mar;24(3):561-76 - PubMed
15. J Natl Compr Canc Netw. 2014 Jun;12(6):916-46 - PubMed
16. Blood. 2005 Dec 1;106(12):3725-32 - PubMed
17. J Clin Oncol. 2009 Sep 20;27(27):4555-62 - PubMed
18. Lancet. 2003 Aug 16;362(9383):516-22 - PubMed
19. Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):928-34 - PubMed
20. J Clin Oncol. 2007 May 20;25(15):1986-92 - PubMed
21. J Clin Oncol. 1997 Mar;15(3):1110-7 - PubMed
22. J Clin Oncol. 2002 Oct 15;20(20):4261-7 - PubMed
23. Blood. 2008 Dec 15;112(13):4824-31 - PubMed
24. Ann Oncol. 1991 Oct;2(9):655-62 - PubMed
25. Haematologica. 2007 Nov;92(11):1482-8 - PubMed
26. Haematologica. 2013 Jul;98(7):1107-14 - PubMed
27. Eur J Haematol. 2010 Jul;85(1):11-9 - PubMed
28. Lancet. 2013 Apr 6;381(9873):1203-10 - PubMed
29. Ann Oncol. 1991 Feb;2 Suppl 2:123-9 - PubMed
30. J Clin Oncol. 1999 Aug;17(8):2499-505 - PubMed

Publication Types

• Journal Article