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Dhandapani S, Aggarwal A, Srinivasan A, et al. Serum lipid profile spectrum and delayed cerebral ischemia following subarachnoid hemorrhage: Is there a relation?. Surg Neurol Int. 2015;6:S543-8doi: 10.4103/2152-7806.168067.
Dhandapani, S., Aggarwal, A., Srinivasan, A., Meena, R., Gaudihalli, S., Singh, H., Dhandapani, M., Mukherjee, K. K., & Gupta, S. K. (2015). Serum lipid profile spectrum and delayed cerebral ischemia following subarachnoid hemorrhage: Is there a relation?. Surgical neurology international, 6S543-8. https://doi.org/10.4103/2152-7806.168067
Dhandapani, Sivashanmugam, et al. "Serum lipid profile spectrum and delayed cerebral ischemia following subarachnoid hemorrhage: Is there a relation?." Surgical neurology international vol. 6 (2015): S543-8. doi: https://doi.org/10.4103/2152-7806.168067
Dhandapani S, Aggarwal A, Srinivasan A, Meena R, Gaudihalli S, Singh H, Dhandapani M, Mukherjee KK, Gupta SK. Serum lipid profile spectrum and delayed cerebral ischemia following subarachnoid hemorrhage: Is there a relation?. Surg Neurol Int. 2015 Oct 23;6:S543-8. doi: 10.4103/2152-7806.168067. eCollection 2015. PMID: 26664869; PMCID: PMC4653325.
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Surg Neurol Int. 2015 Oct 23;6:S543-8. doi: 10.4103/2152-7806.168067. eCollection 2015.

Serum lipid profile spectrum and delayed cerebral ischemia following subarachnoid hemorrhage: Is there a relation?.

Surgical neurology international

Sivashanmugam Dhandapani, Ashish Aggarwal, Anirudh Srinivasan, Rajesh Meena, Sachin Gaudihalli, Harnarayan Singh, Manju Dhandapani, Kanchan K Mukherjee, Sunil K Gupta

Affiliations

  1. Department of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  2. Department of Neurosurgery, Neuro-nursing Division, National Institute of Nursing Education, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

PMID: 26664869 PMCID: PMC4653325 DOI: 10.4103/2152-7806.168067

Abstract

BACKGROUND: Serum lipid abnormalities are known to be important risk factors for vascular disorders. However, their role in delayed cerebral ischemia (DCI), the major cause of morbidity after subarachnoid hemorrhage (SAH) remains unclear. This study was an attempt to evaluate the spectrum of lipid profile changes in SAH compared to matched controls, and their relation with the occurrence of DCI.

METHODS: Admission serum lipid profile levels were measured in patients of SAH and prospectively studied in relation to various factors and clinical development of DCI.

RESULTS: Serum triglyceride (TG) levels were significantly lower among SAH patients compared to matched controls (mean [±standard deviation (SD)] mg/dL: 117.3 [±50.4] vs. 172.8 [±89.1], P = 0.002), probably because of energy consumption due to hypermetabolic response. Patients who developed DCI had significantly higher TG levels compared to those who did not develop DCI (mean [±SD] mg/dL: 142.1 [±56] vs. 111.9 [±54], P = 0.05). DCI was noted in 62% of patients with TG >150 mg/dL, compared to 22% among the rest (P = 0.01). Total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and lipoprotein (a) neither showed a significant difference between SAH and controls and nor any significant association with DCI. Multivariate analysis using binary logistic regression adjusting for the effects of age, sex, systemic disease, World Federation of Neurosurgical Societies grade, Fisher grade, and clipping/coiling, revealed higher TG levels to have significant independent association with DCI (P = 0.01).

CONCLUSIONS: Higher serum TG levels appear to be significantly associated with DCI while other lipid parameters did not show any significant association. This may be due to their association with remnant cholesterol or free fatty acid-induced lipid peroxidation.

Keywords: Cholesterol; delayed cerebral ischemia; lipid; remnant cholesterol; subarachnoid hemorrhage; triglyceride

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