Display options
Cite
Conde Ruiz C, Cruz Benedetti IC, Guillebert I, et al. Effect of Pre- and Postoperative Phenylbutazone and Morphine Administration on the Breathing Response to Skin Incision, Recovery Quality, Behavior, and Cardiorespiratory Variables in Horses Undergoing Fetlock Arthroscopy: A Pilot Study. Front Vet Sci. 2015;2:58doi: 10.3389/fvets.2015.00058.
Conde Ruiz, C., Cruz Benedetti, I. C., Guillebert, I., & Portier, K. G. (2015). Effect of Pre- and Postoperative Phenylbutazone and Morphine Administration on the Breathing Response to Skin Incision, Recovery Quality, Behavior, and Cardiorespiratory Variables in Horses Undergoing Fetlock Arthroscopy: A Pilot Study. Frontiers in veterinary science, 258. https://doi.org/10.3389/fvets.2015.00058
Conde Ruiz, Clara, et al. "Effect of Pre- and Postoperative Phenylbutazone and Morphine Administration on the Breathing Response to Skin Incision, Recovery Quality, Behavior, and Cardiorespiratory Variables in Horses Undergoing Fetlock Arthroscopy: A Pilot Study." Frontiers in veterinary science vol. 2 (2015): 58. doi: https://doi.org/10.3389/fvets.2015.00058
Conde Ruiz C, Cruz Benedetti IC, Guillebert I, Portier KG. Effect of Pre- and Postoperative Phenylbutazone and Morphine Administration on the Breathing Response to Skin Incision, Recovery Quality, Behavior, and Cardiorespiratory Variables in Horses Undergoing Fetlock Arthroscopy: A Pilot Study. Front Vet Sci. 2015 Nov 23;2:58. doi: 10.3389/fvets.2015.00058. eCollection 2015. PMID: 26664985; PMCID: PMC4672197.
Copy Download .nbib Format: NLM
Share it on

Front Vet Sci. 2015 Nov 23;2:58. doi: 10.3389/fvets.2015.00058. eCollection 2015.

Effect of Pre- and Postoperative Phenylbutazone and Morphine Administration on the Breathing Response to Skin Incision, Recovery Quality, Behavior, and Cardiorespiratory Variables in Horses Undergoing Fetlock Arthroscopy: A Pilot Study.

Frontiers in veterinary science

Clara Conde Ruiz, Inga-Catalina Cruz Benedetti, Isabelle Guillebert, Karine Genevieve Portier

Affiliations

  1. Anaesthesiology, Pôle Equin, VetAgro Sup, Lyon University , Marcy L´Etoile , France.
  2. Anaesthesiology, Pôle Equin, VetAgro Sup, Lyon University , Marcy L´Etoile , France ; CarMeN Laboratory, INSERM UMR-1060, University of Lyon , Lyon , France.

PMID: 26664985 PMCID: PMC4672197 DOI: 10.3389/fvets.2015.00058

Abstract

This prospective blinded randomized study aimed to determine whether the timing of morphine and phenylbutazone administration affects the breathing response to skin incision, recovery quality, behavior, and cardiorespiratory variables in horses undergoing fetlock arthroscopy. Ten Standardbred horses were premedicated with acepromazine (0.04 mg kg(-1) IM) and romifidine (0.04 mg kg(-1) IV). Anesthesia was induced with diazepam (0.05 mg kg(-1)) and ketamine (2.2 mg kg(-1)) IV at T0. Horses in group PRE (n = 5) received morphine (0.1 mg kg(-1)) and phenylbutazone (2.2 mg kg(-1)) IV after induction and an equivalent amount of saline after surgery. Horses in group POST (n = 5) received the inversed treatment. Anesthesia was maintained with isoflurane 2% in 100% oxygen. Hypotension (mean arterial pressure <60 mmHg) was treated with dobutamine. All horses breathed spontaneously. Dobutamine requirements, respiratory rate (f R), heart rate (HR), mean arterial blood pressure, end-tidal CO2, inspired (i) and expired (e) tidal and minute volume (V T and [Formula: see text]), inspiratory time (IT), and the inspiratory gas flow (V Ti/IT) were measured every 5 min. Data were averaged during four 15 min periods before (P1 and P2) and after the incision (P3 and P4). Serial blood-gas analyses were also performed. Recoveries were unassisted, video recorded, and scored by three anesthetists blinded to the treatment. The postoperative behavior of the horses (25 demeanors), HR, and f R were recorded at three time points before induction (T0-24 h, T0-12 h, and T0-2 h) and six time points after recovery (TR) (TR + 2, 4, 6, 12, 24, 48 h). Data were compared between groups using a Wilcoxon test and within groups using a Friedman test or a Kruskal-Wallis signed-rank test when applicable. Tidal volumes (V Te and V Ti) were higher in PRE than in POST during all the considered periods but the difference between groups was only significant during P2 (V Te in mL kg(-1) in PRE: 13 [9, 15], in POST: 9 [8, 9], p = 0.01). None of the other variables were significantly different between and within groups. Under our experimental conditions, skin incision did not affect respiratory variables. Administration of pre- versus postoperative phenylbutazone and morphine did not influence recovery quality, HR, f R, or animal behavior.

Keywords: analgesia; breathing response; horses; noxious stimulus; opioids

References

  1. Anesthesiology. 2000 Oct;93(4):1138-43 - PubMed
  2. Br J Anaesth. 2002 May;88(5):649-52 - PubMed
  3. Am J Vet Res. 2003 Feb;64(2):166-75 - PubMed
  4. Clin Pharmacol Ther. 1960 Jul-Aug;1:483-524 - PubMed
  5. Vet Anaesth Analg. 2003 Jul;30(3):124-37 - PubMed
  6. Vet Anaesth Analg. 2003 Jul;30(3):147-55 - PubMed
  7. Vet Anaesth Analg. 2005 Jan;32(1):10-5 - PubMed
  8. Acta Anaesthesiol Scand. 2005 Mar;49(3):284-92 - PubMed
  9. Vet Anaesth Analg. 2005 May;32(3):128-35 - PubMed
  10. Br J Anaesth. 2006 Mar;96(3):367-76 - PubMed
  11. Vet Anaesth Analg. 2006 May;33(3):179-88 - PubMed
  12. Curr Opin Anaesthesiol. 2002 Aug;15(4):435-41 - PubMed
  13. Vet Anaesth Analg. 2008 Jan;35(1):22-9 - PubMed
  14. Vet Anaesth Analg. 2009 May;36(3):209-19 - PubMed
  15. Vet Anaesth Analg. 2009 Jul;36(4):384-95 - PubMed
  16. Equine Vet J. 2010 Apr;42(3):192-9 - PubMed
  17. Vet Anaesth Analg. 2010 Jul;37(4):329-36 - PubMed
  18. Vet Clin North Am Equine Pract. 2010 Dec;26(3):467-80 - PubMed
  19. Vet Clin North Am Equine Pract. 2010 Dec;26(3):493-514 - PubMed
  20. Vet Anaesth Analg. 2011 Sep;38(5):505-9 - PubMed
  21. J Clin Monit Comput. 2011 Aug;25(4):215-21 - PubMed
  22. Can Vet J. 2012 Mar;53(3):257-64 - PubMed
  23. Res Vet Sci. 2013 Dec;95(3):1186-94 - PubMed
  24. Vet Anaesth Analg. 2014 Mar;41(2):109-12 - PubMed
  25. Vet Anaesth Analg. 2002 Oct;29(4):159-170 - PubMed
  26. Equine Vet J. 1988 Sep;20(5):331-4 - PubMed
  27. Res Vet Sci. 1987 Mar;42(2):162-6 - PubMed
  28. Anesthesiology. 1972 Jan;36(1):21-36 - PubMed
  29. Anesthesiology. 1972 Jun;36(6):544-9 - PubMed
  30. Am J Vet Res. 1979 Jul;40(7):978-81 - PubMed
  31. Vet Clin North Am Large Anim Pract. 1981 May;3(1):17-44 - PubMed
  32. Pharmacol Rev. 1983 Dec;35(4):283-323 - PubMed
  33. Am J Vet Res. 1980 May;41(5):821-5 - PubMed
  34. Anesteziol Reanimatol. 1994 Jul-Aug;(4):28-9 - PubMed
  35. Br J Anaesth. 1996 Jun;76(6):777-9 - PubMed
  36. J Appl Physiol (1985). 1996 Dec;81(6):2421-7 - PubMed
  37. Vet Surg. 1997 Mar-Apr;26(2):150-5 - PubMed

Publication Types