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Wilson RJ, Alamanda VK, Hartley KG, et al. Sarcopenia Does Not Affect Survival or Outcomes in Soft-Tissue Sarcoma. Sarcoma. 2015;2015:146481doi: 10.1155/2015/146481.
Wilson, R. J., Alamanda, V. K., Hartley, K. G., Mesko, N. W., Halpern, J. L., Schwartz, H. S., & Holt, G. E. (2015). Sarcopenia Does Not Affect Survival or Outcomes in Soft-Tissue Sarcoma. Sarcoma, 2015146481. https://doi.org/10.1155/2015/146481
Wilson, Robert J, et al. "Sarcopenia Does Not Affect Survival or Outcomes in Soft-Tissue Sarcoma." Sarcoma vol. 2015 (2015): 146481. doi: https://doi.org/10.1155/2015/146481
Wilson RJ, Alamanda VK, Hartley KG, Mesko NW, Halpern JL, Schwartz HS, Holt GE. Sarcopenia Does Not Affect Survival or Outcomes in Soft-Tissue Sarcoma. Sarcoma. 2015;2015:146481. doi: 10.1155/2015/146481. Epub 2015 Dec 01. PMID: 26696772; PMCID: PMC4678075.
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Sarcoma. 2015;2015:146481. doi: 10.1155/2015/146481. Epub 2015 Dec 01.

Sarcopenia Does Not Affect Survival or Outcomes in Soft-Tissue Sarcoma.

Sarcoma

Robert J Wilson, Vignesh K Alamanda, Katherine G Hartley, Nathan W Mesko, Jennifer L Halpern, Herbert S Schwartz, Ginger E Holt

Affiliations

  1. Department of Orthopaedics and Rehabilitation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  2. Department of Orthopaedics, Carolinas Medical Center, Charlotte, NC 28203, USA.
  3. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  4. Department of Orthopaedics, Cleveland Clinic, Cleveland, OH 44195, USA.

PMID: 26696772 PMCID: PMC4678075 DOI: 10.1155/2015/146481

Abstract

Background and Objective. Sarcopenia is associated with decreased survival and increased complications in carcinoma patients. We hypothesized that sarcopenic soft-tissue sarcoma (STS) patients would have decreased survival, increased incidence of wound complications, and increased length of postresection hospital stay (LOS). Methods. A retrospective, single-center review of 137 patients treated surgically for STS was conducted. Sarcopenia was assessed by measuring the cross-sectional area of bilateral psoas muscles (total psoas muscle area, TPA) at the level of the third lumbar vertebrae on a pretreatment axial computed tomography scan. TPA was then adjusted for height (cm(2)/m(2)). The association between height-adjusted TPA and survival was assessed using Cox proportional hazard model. A logistical model was used to assess the association between height-adjusted TPA and wound complications. A linear model was used to assess the association between height-adjusted TPA and LOS. Results. Height-adjusted TPA was not an independent predictor of overall survival (p = 0.746). Patient age (p = 0.02) and tumor size (p = 0.009) and grade (p = 0.001) were independent predictors of overall survival. Height-adjusted TPA was not a predictor of increased hospital LOS (p = 0.66), greater incidence of postoperative infection (p = 0.56), or other wound complications (p = 0.14). Conclusions. Sarcopenia does not appear to impact overall survival, LOS, or wound complications in patients with STS.

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