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Salama A. Clinically and/or Serologically Misleading Findings Surrounding Immune Haemolytic Anaemias. Transfus Med Hemother. 2015;42(5):311-5doi: 10.1159/000438960.
Salama, A. (2015). Clinically and/or Serologically Misleading Findings Surrounding Immune Haemolytic Anaemias. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie, 42(5), 311-5. https://doi.org/10.1159/000438960
Salama, Abdulgabar. "Clinically and/or Serologically Misleading Findings Surrounding Immune Haemolytic Anaemias." Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie vol. 42,5 (2015): 311-5. doi: https://doi.org/10.1159/000438960
Salama A. Clinically and/or Serologically Misleading Findings Surrounding Immune Haemolytic Anaemias. Transfus Med Hemother. 2015 Sep;42(5):311-5. doi: 10.1159/000438960. Epub 2015 Aug 10. PMID: 26696799; PMCID: PMC4678313.
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Transfus Med Hemother. 2015 Sep;42(5):311-5. doi: 10.1159/000438960. Epub 2015 Aug 10.

Clinically and/or Serologically Misleading Findings Surrounding Immune Haemolytic Anaemias.

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

Abdulgabar Salama

Affiliations

  1. Institute for Transfusion Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.

PMID: 26696799 PMCID: PMC4678313 DOI: 10.1159/000438960

Abstract

Autoimmune haemolytic anaemias (AIHAs) are well-characterized disorders. They can be differentiated from one another and from other non-immune haemolytic anaemias by clinical, laboratory and serological testing. However, several misleading clinical presentations and/or serological findings may result in misinterpretation, delay and/or misdiagnosis. Such failures are avoidable by adequate clinical and serological experience of the responsible physicians and serologists or, at least, by an optimised bidirectional communication. As long as this has not been achieved, unpleasant failures are to be expected. A true diagnosis of AIHA can neither be verified by clinical nor serological findings alone. Thus, a collective clinical and serological picture remains obligatory for fulfilling the criteria of optimal diagnosis and therapy. Ultimately, the majority of pioneer scientific and practical work in this field stems from scientists who were simultaneously involved in both the clinic and serology.

Keywords: AIHA; Agglutination; Autoimmune haemolytic anaemia; C3d DAT; Coombs-negative; IgG DAT; Immune haemolysis; Negative DAT; Positive DAT

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