Display options
Cite
Akther S, Huang Z, Liang M, et al. Paternal Retrieval Behavior Regulated by Brain Estrogen Synthetase (Aromatase) in Mouse Sires that Engage in Communicative Interactions with Pairmates. Front Neurosci. 2015;9:450doi: 10.3389/fnins.2015.00450.
Akther, S., Huang, Z., Liang, M., Zhong, J., Fakhrul, A. A., Yuhi, T., Lopatina, O., Salmina, A. B., Yokoyama, S., Higashida, C., Tsuji, T., Matsuo, M., & Higashida, H. (2015). Paternal Retrieval Behavior Regulated by Brain Estrogen Synthetase (Aromatase) in Mouse Sires that Engage in Communicative Interactions with Pairmates. Frontiers in neuroscience, 9450. https://doi.org/10.3389/fnins.2015.00450
Akther, Shirin, et al. "Paternal Retrieval Behavior Regulated by Brain Estrogen Synthetase (Aromatase) in Mouse Sires that Engage in Communicative Interactions with Pairmates." Frontiers in neuroscience vol. 9 (2015): 450. doi: https://doi.org/10.3389/fnins.2015.00450
Akther S, Huang Z, Liang M, Zhong J, Fakhrul AA, Yuhi T, Lopatina O, Salmina AB, Yokoyama S, Higashida C, Tsuji T, Matsuo M, Higashida H. Paternal Retrieval Behavior Regulated by Brain Estrogen Synthetase (Aromatase) in Mouse Sires that Engage in Communicative Interactions with Pairmates. Front Neurosci. 2015 Dec 15;9:450. doi: 10.3389/fnins.2015.00450. eCollection 2015. PMID: 26696812; PMCID: PMC4678232.
Copy Download .nbib Format: NLM
Share it on

Front Neurosci. 2015 Dec 15;9:450. doi: 10.3389/fnins.2015.00450. eCollection 2015.

Paternal Retrieval Behavior Regulated by Brain Estrogen Synthetase (Aromatase) in Mouse Sires that Engage in Communicative Interactions with Pairmates.

Frontiers in neuroscience

Shirin Akther, Zhiqi Huang, Mingkun Liang, Jing Zhong, Azam A K M Fakhrul, Teruko Yuhi, Olga Lopatina, Alla B Salmina, Shigeru Yokoyama, Chiharu Higashida, Takahiro Tsuji, Mie Matsuo, Haruhiro Higashida

Affiliations

  1. Department of Basic Research on Social Recognition, Kanazawa University Research Center for Child Mental Development Kanazawa, Japan.
  2. Department of Basic Research on Social Recognition, Kanazawa University Research Center for Child Mental Development Kanazawa, Japan ; Department of Biochemistry, Medical Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.
  3. Department of Biochemistry, Medical Pharmaceutical and Toxicological Chemistry, Krasnoyarsk State Medical University Krasnoyarsk, Russia.

PMID: 26696812 PMCID: PMC4678232 DOI: 10.3389/fnins.2015.00450

Abstract

Parental behaviors involve complex social recognition and memory processes and interactive behavior with children that can greatly facilitate healthy human family life. Fathers play a substantial role in child care in a small but significant number of mammals, including humans. However, the brain mechanism that controls male parental behavior is much less understood than that controlling female parental behavior. Fathers of non-monogamous laboratory ICR mice are an interesting model for examining the factors that influence paternal responsiveness because sires can exhibit maternal-like parental care (retrieval of pups) when separated from their pups along with their pairmates because of olfactory and auditory signals from the dams. Here we tested whether paternal behavior is related to femininity by the aromatization of testosterone. For this purpose, we measured the immunoreactivity of aromatase [cytochrome P450 family 19 (CYP19)], which synthesizes estrogen from androgen, in nine brain regions of the sire. We observed higher levels of aromatase expression in these areas of the sire brain when they engaged in communicative interactions with dams in separate cages. Interestingly, the number of nuclei with aromatase immunoreactivity in sires left together with maternal mates in the home cage after pup-removing was significantly larger than that in sires housed with a whole family. The capacity of sires to retrieve pups was increased following a period of 5 days spent with the pups as a whole family after parturition, whereas the acquisition of this ability was suppressed in sires treated daily with an aromatase inhibitor. The results demonstrate that the dam significantly stimulates aromatase in the male brain and that the presence of the pups has an inhibitory effect on this increase. These results also suggest that brain aromatization regulates the initiation, development, and maintenance of paternal behavior in the ICR male mice.

Keywords: brain aromatase; communicative interaction; immunoreactivity; mouse; parental behavior; paternal care

References

  1. J Neuroendocrinol. 2005 Sep;17 (9):553-9 - PubMed
  2. J Steroid Biochem Mol Biol. 1997 Apr;61(3-6):375-80 - PubMed
  3. Horm Behav. 2011 Feb;59(2):265-70 - PubMed
  4. J Neurosci. 2010 Oct 6;30(40):13454-60 - PubMed
  5. Front Neurosci. 2014 Sep 02;8:274 - PubMed
  6. Front Endocrinol (Lausanne). 2011 Sep 26;2:40 - PubMed
  7. Brain Res Bull. 1994;33(5):583-8 - PubMed
  8. Mol Brain. 2013 Sep 23;6:41 - PubMed
  9. Science. 2014 Aug 15;345(6198):771-6 - PubMed
  10. Trends Neurosci. 2010 Oct;33(10):465-73 - PubMed
  11. Mol Autism. 2014 Sep 09;5(1):46 - PubMed
  12. Brain Res. 2015 Sep 24;1621:162-9 - PubMed
  13. Neuroreport. 1993 Sep 10;4(11):1247-50 - PubMed
  14. Physiol Behav. 2013 Jun 13;118:159-64 - PubMed
  15. Mol Brain. 2014 Sep 11;7:66 - PubMed
  16. Cell Rep. 2015 Feb 3;10(4):453-62 - PubMed
  17. Nat Commun. 2013;4:1346 - PubMed
  18. Trends Neurosci. 2006 May;29(5):241-9 - PubMed
  19. J Exp Neurosci. 2013 Jul 10;7:31-7 - PubMed
  20. J Reprod Med. 1994 Apr;39(4):257-61 - PubMed
  21. Biochim Biophys Acta. 2010 Oct;1800(10):1094-105 - PubMed
  22. J Histochem Cytochem. 1994 Dec;42(12):1565-73 - PubMed
  23. J Neuroendocrinol. 2011 May;23(5):424-34 - PubMed
  24. Horm Behav. 2002 Feb;41(1):80-7 - PubMed
  25. Neurochem Int. 2012 Nov;61(6):828-38 - PubMed
  26. Br J Cancer. 2011 Mar 29;104(7):1059-66 - PubMed
  27. Front Neurosci. 2014 Jul 11;8:186 - PubMed
  28. Endocrinology. 1998 Apr;139(4):1684-91 - PubMed
  29. Neurosci Lett. 2013 Jun 24;546:63-6 - PubMed
  30. Neuroendocrinology. 2000 Jul;72(1):29-36 - PubMed
  31. Proc Natl Acad Sci U S A. 2003 May 13;100(10):6192-7 - PubMed
  32. Future Child. 2005 Fall;15(2):75-96 - PubMed
  33. Neuroscience. 2015 Sep 24;304:328-39 - PubMed
  34. Neurosci Biobehav Rev. 2011 Jan;35(3):826-47 - PubMed
  35. Mol Cell Endocrinol. 1993 Nov;97(1-2):R1-6 - PubMed
  36. Trends Neurosci. 1998 Jun;21(6):243-9 - PubMed
  37. Eur Neuropsychopharmacol. 2013 Dec;23(12):1724-31 - PubMed
  38. Future Child. 2010 Fall;20(2):87-112 - PubMed
  39. Cell. 2013 May 9;153(4):896-909 - PubMed
  40. Neuroendocrinology. 2003 Jun;77(6):416-24 - PubMed
  41. J Steroid Biochem Mol Biol. 1995 Jun;53(1-6):307-13 - PubMed
  42. Neurosci Lett. 2014 Jun 6;570:21-5 - PubMed
  43. J Marriage Fam. 2014 Apr 1;76(2):370-386 - PubMed
  44. Neurosci Biobehav Rev. 2013 Sep;37(8):1860-74 - PubMed
  45. Brain Res. 2010 Dec 10;1364:198-215 - PubMed
  46. J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):261-77 - PubMed
  47. J Steroid Biochem Mol Biol. 2000 Nov 30;74(5):365-73 - PubMed
  48. Neuroscience. 2011 Sep 15;191:139-47 - PubMed
  49. J Comp Neurol. 1994 May 1;343(1):113-29 - PubMed
  50. Front Neuroendocrinol. 2015 Jan;36:178-96 - PubMed
  51. Science. 2014 Aug 15;345(6198):765-70 - PubMed
  52. J Neuroendocrinol. 2013 Nov;25(11):1070-8 - PubMed
  53. PLoS One. 2013;8(4):e60018 - PubMed
  54. Proc Biol Sci. 2002 Apr 22;269(1493):823-9 - PubMed
  55. Gen Comp Endocrinol. 2011 Jun 1;172(2):211-7 - PubMed
  56. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):481-98 - PubMed
  57. Steroids. 2005 May-Jun;70(5-7):388-96 - PubMed
  58. Horm Behav. 2008 Nov;54(5):748-57 - PubMed
  59. Front Neurosci. 2013 Sep 19;7:159 - PubMed
  60. Front Endocrinol (Lausanne). 2011 Sep 29;2:34 - PubMed
  61. Brain Res Brain Res Rev. 2004 Aug;46(1):71-117 - PubMed
  62. Brain Res. 2006 Dec 18;1126(1):2-26 - PubMed
  63. Science. 1967 Jun 16;156(3781):1512-4 - PubMed
  64. Front Neuroendocrinol. 2006 Sep;27(3):247-74 - PubMed
  65. Neuroendocrinology. 2003 Jul;78(1):36-44 - PubMed
  66. Front Neuroendocrinol. 2009 Jan;30(1):46-64 - PubMed
  67. Behav Brain Res. 2005 Mar 7;158(1):53-68 - PubMed
  68. Neuropsychologia. 2013 Mar;51(4):731-47 - PubMed
  69. Horm Behav. 2013 Mar;63(3):430-6 - PubMed

Publication Types