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Nilsson J, Lebedev AV, Lövdén M. No Significant Effect of Prefrontal tDCS on Working Memory Performance in Older Adults. Front Aging Neurosci. 2015;7:230doi: 10.3389/fnagi.2015.00230.
Nilsson, J., Lebedev, A. V., & Lövdén, M. (2015). No Significant Effect of Prefrontal tDCS on Working Memory Performance in Older Adults. Frontiers in aging neuroscience, 7230. https://doi.org/10.3389/fnagi.2015.00230
Nilsson, Jonna, et al. "No Significant Effect of Prefrontal tDCS on Working Memory Performance in Older Adults." Frontiers in aging neuroscience vol. 7 (2015): 230. doi: https://doi.org/10.3389/fnagi.2015.00230
Nilsson J, Lebedev AV, Lövdén M. No Significant Effect of Prefrontal tDCS on Working Memory Performance in Older Adults. Front Aging Neurosci. 2015 Dec 14;7:230. doi: 10.3389/fnagi.2015.00230. eCollection 2015. PMID: 26696882; PMCID: PMC4677281.
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Front Aging Neurosci. 2015 Dec 14;7:230. doi: 10.3389/fnagi.2015.00230. eCollection 2015.

No Significant Effect of Prefrontal tDCS on Working Memory Performance in Older Adults.

Frontiers in aging neuroscience

Jonna Nilsson, Alexander V Lebedev, Martin Lövdén

Affiliations

  1. Aging Research Center, Karolinska Institutet and Stockholm University Stockholm, Sweden.

PMID: 26696882 PMCID: PMC4677281 DOI: 10.3389/fnagi.2015.00230

Abstract

Transcranial direct current stimulation (tDCS) has been put forward as a non-pharmacological alternative for alleviating cognitive decline in old age. Although results have shown some promise, little is known about the optimal stimulation parameters for modulation in the cognitive domain. In this study, the effects of tDCS over the dorsolateral prefrontal cortex (dlPFC) on working memory performance were investigated in thirty older adults. An N-back task assessed working memory before, during and after anodal tDCS at a current strength of 1 mA and 2 mA, in addition to sham stimulation. The study used a single-blind, cross-over design. The results revealed no significant effect of tDCS on accuracy or response times during or after stimulation, for any of the current strengths. These results suggest that a single session of tDCS over the dlPFC is unlikely to improve working memory, as assessed by an N-back task, in old age.

Keywords: N-back; aging; plasticity; tDCS; working memory

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