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Foronda M, Morgado-Palacin L, Gómez-López G, et al. Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation. Genom Data. 2015;6:21-4doi: 10.1016/j.gdata.2015.07.030.
Foronda, M., Morgado-Palacin, L., Gómez-López, G., Domínguez, O., Pisano, D. G., & Blasco, M. A. (2015). Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation. Genomics data, 621-4. https://doi.org/10.1016/j.gdata.2015.07.030
Foronda, Miguel, et al. "Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation." Genomics data vol. 6 (2015): 21-4. doi: https://doi.org/10.1016/j.gdata.2015.07.030
Foronda M, Morgado-Palacin L, Gómez-López G, Domínguez O, Pisano DG, Blasco MA. Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation. Genom Data. 2015 Aug 03;6:21-4. doi: 10.1016/j.gdata.2015.07.030. eCollection 2015 Dec. PMID: 26697322; PMCID: PMC4664675.
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Genom Data. 2015 Aug 03;6:21-4. doi: 10.1016/j.gdata.2015.07.030. eCollection 2015 Dec.

Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation.

Genomics data

Miguel Foronda, Lucia Morgado-Palacin, Gonzalo Gómez-López, Orlando Domínguez, David G Pisano, Maria A Blasco

Affiliations

  1. Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), C/ Melchor Fernández Almagro, 3, E-28029, Madrid, Spain.
  2. Tumour Suppression Group, Molecular Oncology Program, Spanish National Cancer Research Centre (CNIO), C/ Melchor Fernández Almagro, 3, E-28029, Madrid, Spain.
  3. Bioinformatics Unit, Structural Biology and Biocomputing Program, Spanish National Cancer Research Centre (CNIO), C/ Melchor Fernández Almagro, 3, E-28029, Madrid, Spain.
  4. Genomics Unit, Biotechnology Program, Spanish National Cancer Research Centre (CNIO), C/Melchor Fernández Almagro, 3, E-28029 Madrid, Spain.

PMID: 26697322 PMCID: PMC4664675 DOI: 10.1016/j.gdata.2015.07.030

Abstract

Adult stem cells (ASCs) reside in specific niches in a quiescent state in adult mammals. Upon specific cues they become activated and respond by self-renewing and differentiating into newly generated specialised cells that ensure appropriate tissue fitness. ASC quiescence also serves as a tumour suppression mechanism by hampering cellular transformation and expansion (White AC et al., 2014). Some genes restricted to early embryonic development and adult stem cell niches are often potent modulators of stem cell quiescence, and derailed expression of these is commonly associated to cancer (Vervoort SJ et al., 2013). Among them, it has been shown that recommissioned Sox4 expression facilitates proliferation, survival and migration of malignant cells. By generating a conditional Knockout mouse model in stratified epithelia (Sox4 (cKO) mice), we demonstrated a delayed plucking-induced Anagen in the absence of Sox4. Skin global transcriptome analysis revealed a prominent defect in the induction of transcriptional networks that control hair follicle stem cell (HFSC) activation such as those regulated by Wnt/Ctnnb1, Shh, Myc or Sox9, cell cycle and DNA damage response-associated pathways. Besides, Sox4 (cKO) mice are resistant to skin carcinogenesis, thus linking Sox4 to both normal and pathological HFSC activation (Foronda M et al., 2014). Here we provide additional details on the analysis of Sox4-regulated transcriptome in Telogen and Anagen skin. The raw and processed microarray data is deposited in GEO under GSE58155.

Keywords: Adult stem cells; Cancer; Microarray; Skin; Sox4

References

  1. Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50 - PubMed
  2. Nucleic Acids Res. 2014 Jan;42(Database issue):D472-7 - PubMed
  3. Cell Rep. 2014 Jul 24;8(2):487-500 - PubMed
  4. Nat Rev Mol Cell Biol. 2013 Nov;14(11):737-48 - PubMed
  5. J Invest Dermatol. 2001 Jul;117(1):3-15 - PubMed
  6. Oncogene. 2013 Jul 18;32(29):3397-409 - PubMed
  7. Nat Rev Mol Cell Biol. 2007 Sep;8(9):703-13 - PubMed
  8. Nat Cell Biol. 2014 Jan;16(1):99-107 - PubMed
  9. Cell. 2013 Jun 6;153(6):1194-217 - PubMed
  10. Bioinformatics. 2005 May 1;21(9):2067-75 - PubMed
  11. Bioinformatics. 2007 Oct 15;23(20):2700-7 - PubMed
  12. Genesis. 2004 May;39(1):52-7 - PubMed
  13. Nucleic Acids Res. 2013 Jan;41(Database issue):D991-5 - PubMed
  14. Nat Protoc. 2010 May;5(5):898-911 - PubMed
  15. Nat Cell Biol. 2014 Feb;16(2):179-90 - PubMed
  16. Nucleic Acids Res. 2014 Jan;42(Database issue):D199-205 - PubMed
  17. Cell Stem Cell. 2009 Feb 6;4(2):155-69 - PubMed

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