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Lei K, Sooranna SR, Johnson MR. Expression data from primary culture human myometrial cells. Genom Data. 2015;6:182-3doi: 10.1016/j.gdata.2015.09.008.
Lei, K., Sooranna, S. R., & Johnson, M. R. (2015). Expression data from primary culture human myometrial cells. Genomics data, 6182-3. https://doi.org/10.1016/j.gdata.2015.09.008
Lei, Kaiyu, et al. "Expression data from primary culture human myometrial cells." Genomics data vol. 6 (2015): 182-3. doi: https://doi.org/10.1016/j.gdata.2015.09.008
Lei K, Sooranna SR, Johnson MR. Expression data from primary culture human myometrial cells. Genom Data. 2015 Sep 12;6:182-3. doi: 10.1016/j.gdata.2015.09.008. eCollection 2015 Dec. PMID: 26697367; PMCID: PMC4664736.
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Genom Data. 2015 Sep 12;6:182-3. doi: 10.1016/j.gdata.2015.09.008. eCollection 2015 Dec.

Expression data from primary culture human myometrial cells.

Genomics data

Kaiyu Lei, Suren R Sooranna, Mark R Johnson

Affiliations

  1. Imperial College London, UK.

PMID: 26697367 PMCID: PMC4664736 DOI: 10.1016/j.gdata.2015.09.008

Abstract

Inflammation plays a central role in many human diseases. Human parturition also resembles an inflammatory reaction, where progesterone (P4) and progesterone receptors (PRs) have already been demonstrated to suppress contraction-associated gene expression. In our previous studies, we have found that the progesterone actions, including progesterone-induced gene expression and progesterone's anti-inflammatory effect, are mediated by PR, GR or both. In this study, we used microarrays (GSE68171) to find P4 and IL-1β responsive genes and IL-1β responsive genes which were repressed by P4. These data may provide a broader view of gene networks and cellular functions regulated by P4 and IL-1β in human myometrial cells. These data will also help us understand the role of PR and GR in human parturition.

Keywords: IL-1β; Inflammation; Myometrium; P4; Pregnancy

References

  1. BMC Pregnancy Childbirth. 2013;13 Suppl 1:S7 - PubMed
  2. Mol Endocrinol. 2015 Oct;29(10 ):1454-67 - PubMed

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