Display options
Cite
Harrison BJ, Venkat G, Hutson T, et al. Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model. Genom Data. 2015;6:249-52doi: 10.1016/j.gdata.2015.10.005.
Harrison, B. J., Venkat, G., Hutson, T., Rau, K. K., Bunge, M. B., Mendell, L. M., Gage, F. H., Johnson, R. D., Hill, C., Rouchka, E. C., Moon, L., & Petruska, J. C. (2015). Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model. Genomics data, 6249-52. https://doi.org/10.1016/j.gdata.2015.10.005
Harrison, Benjamin J, et al. "Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model." Genomics data vol. 6 (2015): 249-52. doi: https://doi.org/10.1016/j.gdata.2015.10.005
Harrison BJ, Venkat G, Hutson T, Rau KK, Bunge MB, Mendell LM, Gage FH, Johnson RD, Hill C, Rouchka EC, Moon L, Petruska JC. Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model. Genom Data. 2015 Oct 23;6:249-52. doi: 10.1016/j.gdata.2015.10.005. eCollection 2015 Dec. PMID: 26697387; PMCID: PMC4664766.
Copy Download .nbib Format: NLM
Share it on

Genom Data. 2015 Oct 23;6:249-52. doi: 10.1016/j.gdata.2015.10.005. eCollection 2015 Dec.

Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model.

Genomics data

Benjamin J Harrison, Gayathri Venkat, Thomas Hutson, Kristofer K Rau, Mary Bartlett Bunge, Lorne M Mendell, Fred H Gage, Richard D Johnson, Caitlin Hill, Eric C Rouchka, Lawrence Moon, Jeffrey C Petruska

Affiliations

  1. Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40202, United States ; Kentucky Spinal Cord Injury Research Center (KSCIRC), University of Louisville, Louisville, KY 40202, United States ; Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville, Louisville, KY 40292, United States.
  2. Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40202, United States ; Kentucky Spinal Cord Injury Research Center (KSCIRC), University of Louisville, Louisville, KY 40202, United States.
  3. Wolfson Centre for Age Related Diseases, King's College, London, UK.
  4. Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40202, United States ; Kentucky Spinal Cord Injury Research Center (KSCIRC), University of Louisville, Louisville, KY 40202, United States ; Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40202, United States.
  5. Miami Project to Cure Paralysis, Department of Neurological Surgery and Neurology, University of Miami Miller School of Medicine, Miami, FL, 33136, United States ; Christopher and Dana Reeve Foundation International Consortium on Spinal Cord Injury Research.
  6. Christopher and Dana Reeve Foundation International Consortium on Spinal Cord Injury Research ; Department of Neurobiology and Behavior, State University of New York at Stony Brook, Stony Brook, NY 11794, United States.
  7. Christopher and Dana Reeve Foundation International Consortium on Spinal Cord Injury Research ; Laboratory of Genetics, The Salk Institute, La Jolla, CA 92037, United States.
  8. Department of Physiological Sciences, University of Florida, Gainesville, FL 32210, United States ; McKnight Brain Institute at the University of Florida, Gainesville, FL 32611, United States.
  9. Weill Medical College of Cornell University, Brain and Mind Research Institute, New York, NY, United States ; Burke Medical Research Institute, White Plains, NY 10605, United States.
  10. Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville, Louisville, KY 40292, United States ; Department of Computer Engineering and Computer Science, University of Louisville, Louisville, KY 40292, United States.
  11. Department of Anatomical Sciences and Neurobiology, University of Louisville, Louisville, KY 40202, United States ; Kentucky Spinal Cord Injury Research Center (KSCIRC), University of Louisville, Louisville, KY 40202, United States ; Department of Neurosurgery, University of Louisville, Louisville, KY 40202, United States.

PMID: 26697387 PMCID: PMC4664766 DOI: 10.1016/j.gdata.2015.10.005

Abstract

Primary afferent collateral sprouting is a process whereby non-injured primary afferent neurons respond to some stimulus and extend new branches from existing axons. Neurons of both the central and peripheral nervous systems undergo this process, which contributes to both adaptive and maladaptive plasticity (e.g., [1], [2], [3], [4], [5], [6], [7], [8], [9]). In the model used here (the "spared dermatome" model), the intact sensory neurons respond to the denervation of adjacent areas of skin by sprouting new axon branches into that adjacent denervated territory. Investigations of gene expression changes associated with collateral sprouting can provide a better understanding of the molecular mechanisms controlling this process. Consequently, it can be used to develop treatments to promote functional recovery for spinal cord injury and other similar conditions. This report includes raw gene expression data files from microarray experiments in order to study the gene regulation in spared sensory ganglia in the initiation (7 days) and maintenance (14 days) phases of the spared dermatome model relative to intact ("naïve") sensory ganglia. Data has been deposited into GEO (GSE72551).

Keywords: Axon growth; Axonal plasticity; Nerve injury; Pain; Transcriptomics

References

  1. J Neurosci. 1999 Sep 1;19(17):7405-14 - PubMed
  2. Circ Res. 2000 Apr 14;86(7):816-21 - PubMed
  3. J Neurotrauma. 2002 Dec;19(12):1531-41 - PubMed
  4. Cardiovasc Res. 2001 May;50(2):409-16 - PubMed
  5. J Auton Nerv Syst. 1995 Jun 25;53(2-3):205-14 - PubMed
  6. J Comp Neurol. 1984 Jul 1;226(3):336-45 - PubMed
  7. Eur J Neurosci. 1996 Jun;8(6):1240-8 - PubMed
  8. J Neurophysiol. 1988 Aug;60(2):446-62 - PubMed
  9. J Neurosci. 1992 Apr;12(4):1454-66 - PubMed
  10. Proc Natl Acad Sci U S A. 1987 Sep;84(18):6596-600 - PubMed
  11. Neurosci Lett. 1989 Feb 13;97(1-2):118-22 - PubMed
  12. Exp Neurol. 1997 Nov;148(1):51-72 - PubMed
  13. J Pain. 2010 Nov;11(11):1066-73 - PubMed
  14. J Comp Neurol. 2014 Apr 1;522(5):1048-71 - PubMed
  15. Nucleic Acids Res. 2002 Jan 1;30(1):207-10 - PubMed
  16. Exp Brain Res. 1984;55(3):395-401 - PubMed
  17. Neuroscientist. 2003 Feb;9(1):64-75 - PubMed
  18. Exp Neurol. 2005 Jun;193(2):291-311 - PubMed

Publication Types

Grant support