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Beesley SJ, Lanspa MJ. Why we need a new definition of sepsis. Ann Transl Med. 2015;3(19):296doi: 10.3978/j.issn.2305-5839.2015.11.02.
Beesley, S. J., & Lanspa, M. J. (2015). Why we need a new definition of sepsis. Annals of translational medicine, 3(19), 296. https://doi.org/10.3978/j.issn.2305-5839.2015.11.02
Beesley, Sarah J, and Lanspa, Michael J. "Why we need a new definition of sepsis." Annals of translational medicine vol. 3,19 (2015): 296. doi: https://doi.org/10.3978/j.issn.2305-5839.2015.11.02
Beesley SJ, Lanspa MJ. Why we need a new definition of sepsis. Ann Transl Med. 2015 Nov;3(19):296. doi: 10.3978/j.issn.2305-5839.2015.11.02. PMID: 26697456; PMCID: PMC4671881.
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Ann Transl Med. 2015 Nov;3(19):296. doi: 10.3978/j.issn.2305-5839.2015.11.02.

Why we need a new definition of sepsis.

Annals of translational medicine

Sarah J Beesley, Michael J Lanspa

Affiliations

  1. 1 Pulmonary and Critical Care, University of Utah School of Medicine, Salt Lake City, UT, USA ; 2 Pulmonary and Critical Care, Intermountain Medical Center, Salt Lake City, UT, USA.

PMID: 26697456 PMCID: PMC4671881 DOI: 10.3978/j.issn.2305-5839.2015.11.02

Abstract

On April 23, 2015, Kaukonen and colleagues published an article in the New England Journal of Medicine entitled "Systemic inflammatory response syndrome criteria in defining severe sepsis", which investigated the sensitivity and validity of using SIRS criteria to define intensive care unit (ICU) patients with severe sepsis. This study used admission data of over 100,000 patients in order to investigate patients with severe sepsis who either met or didn't meet SIRS criteria. The investigators found that in-hospital mortality increased linearly with the number of SIRS criteria met; raising concern that SIRS criterion is not sensitive enough. This study of SIRS criteria raises important questions about the recognition and diagnosis of severe sepsis.

Keywords: Sepsis; systemic inflammatory response syndrome (SIRS)

References

  1. Crit Care Med. 2001 Apr;29(4):880-6 - PubMed
  2. N Engl J Med. 2015 Apr 23;372(17):1629-38 - PubMed
  3. Crit Care Med. 2003 Apr;31(4):1250-6 - PubMed
  4. Intensive Care Med. 2006 Mar;32(3):421-7 - PubMed
  5. Crit Care Med. 1997 Feb;25(2):372-4 - PubMed
  6. Intensive Care Med. 2013 Feb;39(2):165-228 - PubMed
  7. Crit Care Med. 2002 Mar;30(3):706-8 - PubMed
  8. Crit Care Med. 2000 Jan;28(1):232-5 - PubMed
  9. Chest. 2011 Jul;140(1):156-63 - PubMed
  10. N Engl J Med. 2014 May 1;370(18):1683-93 - PubMed
  11. Intensive Care Med. 2003 Apr;29(4):530-8 - PubMed
  12. Shock. 2000 Dec;14(6):586-9 - PubMed
  13. Intensive Care Med. 2000;26 Suppl 1:S64-74 - PubMed
  14. Crit Care Med. 2004 Mar;32(3):858-73 - PubMed
  15. Am J Clin Pathol. 2011 Feb;135(2):182-9 - PubMed
  16. Intensive Care Med. 2000 Dec;26(12 ):1870 - PubMed
  17. N Engl J Med. 2014 Oct 16;371(16):1496-506 - PubMed
  18. Intensive Care Med. 2000 Mar;26 Suppl 2:S148-52 - PubMed
  19. N Engl J Med. 2015 Apr 2;372(14):1301-11 - PubMed
  20. Chest. 1992 Jun;101(6):1644-55 - PubMed
  21. Intensive Care Med. 2008 Jan;34(1):17-60 - PubMed
  22. JAMA. 1995 Jan 11;273(2):117-23 - PubMed
  23. J Int Med Res. 2013 Oct;41(5):1671-81 - PubMed

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