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Br J Clin Pharmacol. 1979 Apr;8:163S-6S. doi: 10.1111/j.1365-2125.1979.tb04774.x.

A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension.

British journal of clinical pharmacology

J J McNeil, W J Louis

PMID: 26635160 DOI: 10.1111/j.1365-2125.1979.tb04774.x

Abstract

1 This study was designed to compare in a double-blind randomized crossover trial, atenolol, labetalol, metoprolol and pindolol. Considerable differences in dose (atenolol 138 +/- 13 mg daily; labetalol 308 +/- 34 mg daily; metoprolol 234 +/- 22 mg daily; and pindolol 24 +/-2 mg daily were required to produce similar antihypertensive effects. 3 The overall incidence of side-effects was similar with atenolol, metoprolol and pindolol but was slightly less with labetalol. Sleep disturbances and abnormal dreaming patterns were most frequent with pindolol. 4 There was a significantly greater fall in pulse rate during atenolol and metoprolol treatment periods.

1979 The British Pharmacological Society.

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