Br J Clin Pharmacol. 1979 Apr;8:217S-22S. doi: 10.1111/j.1365-2125.1979.tb04784.x.
British journal of clinical pharmacology
G D Lamming, E B Symonds
PMID: 26635170 DOI: 10.1111/j.1365-2125.1979.tb04784.x
1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with labetalol, and daily BP control was better in this group. 3 Two severely hypertensive patients were successfully treated with intravenous labetalol. 4 There was a higher incidence of spontaneous labour in the labetalol group and a significant difference (P less than 0.05) in the Bishop score of the cervix between the two groups. 5 There were no apparent detrimental effects on the foetus antenatally, during labour or post partum. 6 Slight breathlessness in one patient treated with labetalol was the only side-effect observed but drowsiness, headache and postural hypotension were reported in patients receiving methyldopa.
1979 The British Pharmacological Society.
