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Adiels M, Mardinoglu A, Taskinen MR, et al. Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans. Front Physiol. 2015;6:342doi: 10.3389/fphys.2015.00342.
Adiels, M., Mardinoglu, A., Taskinen, M. R., & Borén, J. (2015). Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans. Frontiers in physiology, 6342. https://doi.org/10.3389/fphys.2015.00342
Adiels, Martin, et al. "Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans." Frontiers in physiology vol. 6 (2015): 342. doi: https://doi.org/10.3389/fphys.2015.00342
Adiels M, Mardinoglu A, Taskinen MR, Borén J. Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans. Front Physiol. 2015 Nov 20;6:342. doi: 10.3389/fphys.2015.00342. eCollection 2015. PMID: 26635628; PMCID: PMC4653309.
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Front Physiol. 2015 Nov 20;6:342. doi: 10.3389/fphys.2015.00342. eCollection 2015.

Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.

Frontiers in physiology

Martin Adiels, Adil Mardinoglu, Marja-Riitta Taskinen, Jan Borén

Affiliations

  1. Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg Gothenburg, Sweden ; Health Metrics Unit, Sahlgrenska Academy, University of Gothenburg Gothenburg, Sweden.
  2. Department of Biology and Biological Engineering, Chalmers University of Technology Gothenburg, Sweden ; Science for Life Laboratory, KTH - Royal Institute of Technology Stockholm, Sweden.
  3. Heart and Lung Centre, Helsinki University Hospital and Research Programs' Unit, Diabetes & Obesity, University of Helsinki Helsinki, Finland.
  4. Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg Gothenburg, Sweden.

PMID: 26635628 PMCID: PMC4653309 DOI: 10.3389/fphys.2015.00342

Abstract

To develop novel strategies for prevention and treatment of dyslipidemia, it is essential to understand the pathophysiology of dyslipoproteinemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion, and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labeled with stable isotopes and mathematical modeling, provides us with a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering our understanding of the pathogenesis of dyslipoproteinemia.

Keywords: apoB; kinetics; multocomnpartmental modeling; stable isotopes; very low density lipoproteins

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