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Yousuf T, Brinton T, Kramer J, et al. Correlation Between Partial Pressure of Arterial Carbon Dioxide and End Tidal Carbon Dioxide in Patients with Severe Alcohol Withdrawal. Ochsner J. 2015;15(4):418-22
Yousuf, T., Brinton, T., Kramer, J., Khan, B., Ziffra, J., Villines, D., Shah, P., & Hanif, T. (2015). Correlation Between Partial Pressure of Arterial Carbon Dioxide and End Tidal Carbon Dioxide in Patients with Severe Alcohol Withdrawal. The Ochsner journal, 15(4), 418-22.
Yousuf, Tariq, et al. "Correlation Between Partial Pressure of Arterial Carbon Dioxide and End Tidal Carbon Dioxide in Patients with Severe Alcohol Withdrawal." The Ochsner journal vol. 15,4 (2015): 418-22.
Yousuf T, Brinton T, Kramer J, Khan B, Ziffra J, Villines D, Shah P, Hanif T. Correlation Between Partial Pressure of Arterial Carbon Dioxide and End Tidal Carbon Dioxide in Patients with Severe Alcohol Withdrawal. Ochsner J. 2015;15(4):418-22. PMID: 26730226; PMCID: PMC4679303.
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Ochsner J. 2015;15(4):418-22.

Correlation Between Partial Pressure of Arterial Carbon Dioxide and End Tidal Carbon Dioxide in Patients with Severe Alcohol Withdrawal.

The Ochsner journal

Tariq Yousuf, Taylor Brinton, Jason Kramer, Basharath Khan, Jeffrey Ziffra, Dana Villines, Poorvi Shah, Tabassum Hanif

Affiliations

  1. Department of Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL.
  2. Rosalind Franklin University of Medicine and Science, Chicago, IL.
  3. Department of Research, Advocate Christ Medical Center, Oak Lawn, IL.
  4. Department of Pharmacy, Advocate Christ Medical Center, Oak Lawn, IL.
  5. Department of Pulmonary/Critical Care Medicine, Advocate Christ Medical Center, Oak Lawn, IL.

PMID: 26730226 PMCID: PMC4679303

Abstract

BACKGROUND: Respiratory depression is a common adverse effect of benzodiazepine administration to patients with severe alcoholic withdrawal. This study was conducted to assess the value of end tidal carbon dioxide (ETCO2) levels compared to partial pressure of arterial carbon dioxide (PaCO2) levels in monitoring respiratory depression secondary to benzodiazepine treatment in patients with severe alcohol withdrawal.

METHODS: We retrospectively analyzed 36 patients admitted to the intensive care unit for severe alcohol withdrawal who had been administered sedative agents.

RESULTS: We observed a statistically significant correlation between PaCO2 and ETCO2 at time 1 (r=0.74, P<0.01) and time 3 (r=0.52, P=0.02) but not at time 2 (r=0.22, P=0.31).

CONCLUSION: Our study confirms a positive correlation between PaCO2 and ETCO2 levels in patients experiencing severe alcohol withdrawal.

Keywords: Alcohol withdrawal delirium; blood gas analysis; capnography; respiratory insufficiency

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