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Janiak A, Leśniowski B, Jasińska A, et al. Interleukin 18 as an early marker or prognostic factor in acute pancreatitis. Prz Gastroenterol. 2015;10(4):203-7doi: 10.5114/pg.2015.50993.
Janiak, A., Leśniowski, B., Jasińska, A., Pietruczuk, M., & Małecka-Panas, E. (2015). Interleukin 18 as an early marker or prognostic factor in acute pancreatitis. Przeglad gastroenterologiczny, 10(4), 203-7. https://doi.org/10.5114/pg.2015.50993
Janiak, Adam, et al. "Interleukin 18 as an early marker or prognostic factor in acute pancreatitis." Przeglad gastroenterologiczny vol. 10,4 (2015): 203-7. doi: https://doi.org/10.5114/pg.2015.50993
Janiak A, Leśniowski B, Jasińska A, Pietruczuk M, Małecka-Panas E. Interleukin 18 as an early marker or prognostic factor in acute pancreatitis. Prz Gastroenterol. 2015;10(4):203-7. doi: 10.5114/pg.2015.50993. Epub 2015 Apr 20. PMID: 26759626; PMCID: PMC4697031.
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Prz Gastroenterol. 2015;10(4):203-7. doi: 10.5114/pg.2015.50993. Epub 2015 Apr 20.

Interleukin 18 as an early marker or prognostic factor in acute pancreatitis.

Przeglad gastroenterologiczny

Adam Janiak, Bartosz Leśniowski, Anna Jasińska, Mirosława Pietruczuk, Ewa Małecka-Panas

Affiliations

  1. Department of General and Transplantological Surgery, Medical University of Lodz, Lodz, Poland.
  2. Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
  3. Department of Laboratory Diagnostics, Medical University of Lodz, Lodz, Poland.

PMID: 26759626 PMCID: PMC4697031 DOI: 10.5114/pg.2015.50993

Abstract

INTRODUCTION: Acute pancreatits (AP) still reqiures better diagnostic and therapeutic options to be introduced in order to decrease its morbidity and mortality. It appears that the assessment of serum levels of interleukin 18 (IL-18) and its correlation with C-reactive protein (CRP) may provide adequate prognostic value.

AIM: To measure serum concentrations of IL-18 and inflammation markers such as CRP in patients with AP during subsequent hospital stay days and to assess the role of IL-18 as an early AP marker and prognostic factor.

MATERIAL AND METHODS: Thirty-two patients aged 47 ±16.7 years were included into the study (17 males and 15 females), in whom AP was diagnosed based on ultrasound and computer aided tomography imaging and amylase. Serum amylase, CRP, and IL-18 levels were measured on the 1(st), 2(nd), 3(rd), and 5(th) days of hospital stay. All patients were scored "B" according to Balthazar and mild AP based on Ranson criteria. The control group consisted of 30 healthy volunteers aged 50.7 ±12.4 years (15 males and 15 females).

RESULTS: The average IL-18 serum level in the control group was 86.91 ±4.94 pg/ml. Mean IL-18 study group levels were 128.4 ±7.6 pg/ml on the 1(st), 112.0 ±4.4 pg/ml on the 3(rd), and 122.8 ±6.8 pg/ml on the 5(th) day of AP, and were significantly higher than those in the control group, accordingly: p < 0.001, p < 0.005, p < 0.001. A positive correlation between IL-18 and CRP serum concentrations was observed. A slight increase in correlation was observed as the days went by.

CONCLUSIONS: We concluded that the serum IL-18 level increases in the initial phase of AP, and it may be used as an inflammatory reaction marker in patients with AP, and it is correlated with CRP, which may indicate its prognostic role in AP.

Keywords: C-reactive protein; acute pancreatitis; interleukin 18

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