Display options
Cite
Laks R, Araújo LM, Almada Filho Cde M, et al. The importance of HDL-C and CRP in cardiovascular risk evaluation in longevous elderly individuals. Einstein (Sao Paulo). 2011;9(3):397-403doi: 10.1590/S1679-45082011RW1953.
Laks, R., Araújo, L. M., Almada Filho, C. d. e. . M., & Cendoroglo, M. S. (2011). The importance of HDL-C and CRP in cardiovascular risk evaluation in longevous elderly individuals. Einstein (Sao Paulo, Brazil), 9(3), 397-403. https://doi.org/10.1590/S1679-45082011RW1953
Laks, Renato, et al. "The importance of HDL-C and CRP in cardiovascular risk evaluation in longevous elderly individuals." Einstein (Sao Paulo, Brazil) vol. 9,3 (2011): 397-403. doi: https://doi.org/10.1590/S1679-45082011RW1953
Laks R, Araújo LM, Almada Filho Cde M, Cendoroglo MS. The importance of HDL-C and CRP in cardiovascular risk evaluation in longevous elderly individuals. Einstein (Sao Paulo). 2011 Sep;9(3):397-403. doi: 10.1590/S1679-45082011RW1953. Portuguese. PMID: 26761114.
Copy Download .nbib Format: NLM
Share it on

Einstein (Sao Paulo). 2011 Sep;9(3):397-403. doi: 10.1590/S1679-45082011RW1953.

The importance of HDL-C and CRP in cardiovascular risk evaluation in longevous elderly individuals.

Einstein (Sao Paulo, Brazil)

[Article in Portuguese]
Renato Laks, Lara Miguel Quirino Araújo, Clineu de Mello Almada Filho, Maysa Seabra Cendoroglo

Affiliations

  1. Department of Geriatrics and Gerontology, Escola Paulista de Medicina, Universidade Federal de São Paulo - UNIFESP, Sao Paulo, SP, BR.

PMID: 26761114 DOI: 10.1590/S1679-45082011RW1953

Abstract

The association between total mortality, lipoproteinS, and inflammatory markers, and their implications with aging and longevity are often controversial. Among the most often studied markers are low HDL cholesterol and high C-reactive protein. Particularly in octogenarians, it is expected that the impact of the inclusion of HDL cholesterol and C-reactive protein will improve the stratification of absolute cardiovascular risk. In the present study, we performed a literature review in PubMed about the relation between HDL cholesterol, inflammation and longevity. Applying the inclusion and exclusion criteria adopted, we selected 30 studies, among which one systematic review on the relation between HDL cholesterol and stroke, one meta-analysis on the relation between total cholesterol and HDL cholesterol with mortality, 22 longitudinal studies, and six cross-sectional studies. The results show an inverse association between HDL cholesterol and total mortality, and between cardiovascular mortality and C-reactive protein, as well as a positive association between C-reactive protein and mortality in longevous individuals. C-reactive protein and HDL cholesterol displayed promising characteristics as predictors of cardiovascular mortality in longevous elderly persons.

Publication Types