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Doguizi S, Sekeroglu MA, Anayol MA, et al. Arginine-Restricted Therapy Resistant Bilateral Macular Edema Associated with Gyrate Atrophy. Case Rep Ophthalmol Med. 2015;2015:137270doi: 10.1155/2015/137270.
Doguizi, S., Sekeroglu, M. A., Anayol, M. A., & Yilmazbas, P. (2015). Arginine-Restricted Therapy Resistant Bilateral Macular Edema Associated with Gyrate Atrophy. Case reports in ophthalmological medicine, 2015137270. https://doi.org/10.1155/2015/137270
Doguizi, Sibel, et al. "Arginine-Restricted Therapy Resistant Bilateral Macular Edema Associated with Gyrate Atrophy." Case reports in ophthalmological medicine vol. 2015 (2015): 137270. doi: https://doi.org/10.1155/2015/137270
Doguizi S, Sekeroglu MA, Anayol MA, Yilmazbas P. Arginine-Restricted Therapy Resistant Bilateral Macular Edema Associated with Gyrate Atrophy. Case Rep Ophthalmol Med. 2015;2015:137270. doi: 10.1155/2015/137270. Epub 2015 Dec 06. PMID: 26770854; PMCID: PMC4684840.
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Case Rep Ophthalmol Med. 2015;2015:137270. doi: 10.1155/2015/137270. Epub 2015 Dec 06.

Arginine-Restricted Therapy Resistant Bilateral Macular Edema Associated with Gyrate Atrophy.

Case reports in ophthalmological medicine

Sibel Doguizi, Mehmet Ali Sekeroglu, Mustafa Alpaslan Anayol, Pelin Yilmazbas

Affiliations

  1. Ulucanlar Eye Training and Research Hospital, Department of Ophthalmology, 06240 Ankara, Turkey.

PMID: 26770854 PMCID: PMC4684840 DOI: 10.1155/2015/137270

Abstract

Introduction. Gyrate atrophy is a rare genetical metabolic disorder affecting vision. Here, we report a 9-year-old boy with gyrate atrophy associated with bilateral macular edema at the time of diagnosis and the effect of long term metabolic control on macular edema. Case Presentation. A 9-year-old boy presented with a complaint of low visual acuity (best corrected visual acuity: 20/80 in both eyes, refractive error: -12.00 D). Dilated fundus examination revealed multiple bilateral, sharply defined, and scalloped chorioretinal atrophy areas in the midperipheral and peripheral zone. Spectral-domain optical coherence tomography revealed bilateral cystoid macular edema in both eyes. Serum ornithine level was high (622 μmol/L). An arginine-restricted diet reduced serum ornithine level (55 μmol/L). However, visual findings including macular edema remained unchanged in 2 years of follow-up. Conclusion. Arginine-restricted diet did not improve macular edema in our patient with gyrate atrophy. A more comprehensive understanding of the underlying factors for macular edema will lead to the development of effective therapies.

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