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Pusponegoro HD, Ismael S, Sastroasmoro S, et al. Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder. Pediatr Gastroenterol Hepatol Nutr. 2015;18(4):230-7doi: 10.5223/pghn.2015.18.4.230.
Pusponegoro, H. D., Ismael, S., Sastroasmoro, S., Firmansyah, A., & Vandenplas, Y. (2015). Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder. Pediatric gastroenterology, hepatology & nutrition, 18(4), 230-7. https://doi.org/10.5223/pghn.2015.18.4.230
Pusponegoro, Hardiono D, et al. "Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder." Pediatric gastroenterology, hepatology & nutrition vol. 18,4 (2015): 230-7. doi: https://doi.org/10.5223/pghn.2015.18.4.230
Pusponegoro HD, Ismael S, Sastroasmoro S, Firmansyah A, Vandenplas Y. Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder. Pediatr Gastroenterol Hepatol Nutr. 2015 Dec;18(4):230-7. doi: 10.5223/pghn.2015.18.4.230. Epub 2015 Dec 23. PMID: 26770897; PMCID: PMC4712535.
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Pediatr Gastroenterol Hepatol Nutr. 2015 Dec;18(4):230-7. doi: 10.5223/pghn.2015.18.4.230. Epub 2015 Dec 23.

Maladaptive Behavior and Gastrointestinal Disorders in Children with Autism Spectrum Disorder.

Pediatric gastroenterology, hepatology & nutrition

Hardiono D Pusponegoro, Sofyan Ismael, Sudigdo Sastroasmoro, Agus Firmansyah, Yvan Vandenplas

Affiliations

  1. Department of Child Health, Medical School, University of Indonesia, Jakarta, Indonesia.
  2. Department of Pediatrics, Universitair Ziekenhuis Brussel, Brussels, Belgium.

PMID: 26770897 PMCID: PMC4712535 DOI: 10.5223/pghn.2015.18.4.230

Abstract

PURPOSE: Various gastrointestinal factors may contribute to maladaptive behavior in children with autism spectrum disorders (ASD). To determine the association between maladaptive behavior in children with ASD and gastrointestinal symptoms such as severity, intestinal microbiota, inflammation, enterocyte damage, permeability and absorption of opioid peptides.

METHODS: This observational cross-sectional study compared children with ASD to healthy controls, aged 2-10 years. Maladaptive behavior was classified using the Approach Withdrawal Problems Composite subtest of the Pervasive Developmental Disorder Behavior Inventory. Dependent variables were gastrointestinal symptom severity index, fecal calprotectin, urinary D-lactate, urinary lactulose/mannitol excretion, urinary intestinal fatty acids binding protein (I-FABP) and urinary opioid peptide excretion.

RESULTS: We did not find a significant difference between children with ASD with severe or mild maladaptive behavior and control subjects for gastrointestinal symptoms, fecal calprotectin, urinary D-lactate, and lactulose/mannitol ratio. Urinary opioid peptide excretion was absent in all children. Children with ASD with severe maladaptive behavior showed significantly higher urinary I-FABP levels compared to those with mild maladaptive behavior (p=0.019) and controls (p=0.015).

CONCLUSION: In our series, maladaptive behavior in ASD children was not associated with gastrointestinal symptoms, intestinal inflammation (no difference in calprotectin), microbiota (no difference in urinary D-lactate) and intestinal permeability (no difference in lactulose/manitol ratio). ASD children with severe maladaptive behavior have significantly more enterocyte damage (increased urinary I-FABP) than ASD children with mild maladaptive behavior and normal children.

Keywords: Autism spectrum disorder; Enterocyte damage; Intestinal inflammation; Intestinal permeability; Urinary opioids

References

  1. J Pediatr Gastroenterol Nutr. 2010 Oct;51(4):418-24 - PubMed
  2. Autism. 2009 Jul;13(4):343-55 - PubMed
  3. J Autism Dev Disord. 2008 Feb;38(2):401-6 - PubMed
  4. J Autism Dev Disord. 2014 May;44(5):1117-27 - PubMed
  5. Arch Dis Child. 2008 Sep;93(9):745-50 - PubMed
  6. Child Care Health Dev. 2010 May;36(3):437-43 - PubMed
  7. Anal Bioanal Chem. 2007 Aug;388(8):1643-51 - PubMed
  8. Br Med J. 1972 Sep 2;3(5826):566-9 - PubMed
  9. Autism Res. 2009 Aug;2(4):232-6 - PubMed
  10. Autism Res. 2012 Dec;5(6):419-27 - PubMed
  11. J Dev Behav Pediatr. 2011 Jun;32(5):351-60 - PubMed
  12. BMJ Open. 2014 May 02;4(5):e004558 - PubMed
  13. MMWR Surveill Summ. 2012 Mar 30;61(3):1-19 - PubMed
  14. Eur J Pediatr. 2008 Oct;167(10):1091-101 - PubMed
  15. Neonatology. 2010 Jun;97(4):299-304 - PubMed
  16. J Am Acad Child Adolesc Psychiatry. 2010 Mar;49(3):267-76 - PubMed
  17. Indian Pediatr. 2013 Jan 8;50(1):152-3 - PubMed
  18. Nutr Neurosci. 2003 Feb;6(1):19-28 - PubMed
  19. Acta Paediatr. 2007 Jul;96(7):1076-9 - PubMed
  20. World J Gastrointest Surg. 2010 Mar 27;2(3):61-9 - PubMed
  21. Cell Mol Neurobiol. 2010 Mar;30(2):161-71 - PubMed
  22. Autism Res. 2012 Apr;5(2):101-8 - PubMed
  23. Pediatrics. 2009 Aug;124(2):680-6 - PubMed
  24. Pediatrics. 2010 Jan;125 Suppl 1:S1-18 - PubMed
  25. Environ Health Perspect. 2006 Jul;114(7):1119-25 - PubMed
  26. Scand J Gastroenterol. 2011 Dec;46(12):1435-41 - PubMed
  27. Pediatrics. 2009 Mar;123(3):1018-24 - PubMed
  28. J Autism Dev Disord. 2009 May;39(5):796-805 - PubMed
  29. Microb Ecol Health Dis. 2015 May 29;26:28177 - PubMed

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