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Schlottfeldt Fdos S, Fernandes SM, Martins DM, et al. Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos. Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication. Rev Esc Enferm USP. 2015;49:74-9doi: 10.1590/S0080-623420150000700011.
Schlottfeldt, F. d. o. s. . S., Fernandes, S. M., Martins, D. M., Cordeiro, P., Fonseca, C. D., Watanabe, M., & Vattimo, M. d. e. . F. (2015). Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos. Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication. Revista da Escola de Enfermagem da U S P, 4974-9. https://doi.org/10.1590/S0080-623420150000700011
Schlottfeldt, Fábio Dos Santos, et al. "Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos." Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication. Revista da Escola de Enfermagem da U S P vol. 49 (2015): 74-9. doi: https://doi.org/10.1590/S0080-623420150000700011
Schlottfeldt Fdos S, Fernandes SM, Martins DM, Cordeiro P, Fonseca CD, Watanabe M, Vattimo Mde F. Prevenção da nefrotoxicidade da anfotericina B por meio do uso de fitomedicamentos. Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication. Rev Esc Enferm USP. 2015 Feb;49:74-9. doi: 10.1590/S0080-623420150000700011. Portuguese. PMID: 26761695.
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Rev Esc Enferm USP. 2015 Feb;49:74-9. doi: 10.1590/S0080-623420150000700011.

Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication.

Revista da Escola de Enfermagem da U S P

[Article in Portuguese]
Fábio Dos Santos Schlottfeldt, Sheila Marques Fernandes, Daniel Malisani Martins, Priscilla Cordeiro, Cassiane Dezoti da Fonseca, Mirian Watanabe, Maria de Fatima Fernandes Vattimo

Affiliations

  1. Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.
  2. Departamento de Enfermagem Médico Cirúrgica, Escola de Enfermagem, Universidade de São Paulo, São Paulo, SP, Brasil.

PMID: 26761695 DOI: 10.1590/S0080-623420150000700011

Abstract

Objective To evaluate the effect of diosmin and hesperidin flavonoids in the prevention of amphotericin B nephrotoxicity, through an experimental model on rats. Method Adult, male Wistar rats were distributed into the following groups: saline; diosmin hesperidin (animals that received 50 mg/kg of diosmin hesperidin, drinking water, for ten days); amphotericin B (animals that received 15 mg/kg/day of amphotericin B through intraperitoneal treatment for five days); amphotericin B+diosmin hesperidin. Renal function, fractional excretion of sodium; potassium and magnesium and oxidative metabolites were evaluated. Results Treatment with amphotericin B reduced renal function, as shown by the clearance of creatinine, increased tubular function markers and fractional excretion of sodium, potassium, magnesium and oxidative metabolites. Pre-treatment with diosmin hesperidin ameliorated clearance of creatinine and reduced tubular and oxidative injury. Conclusion Administration of amphotericin B resulted in reduction of renal function with tubular injury, and diosmin hesperidin showing an antioxidant protective effect on the kidneys.

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