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Elzi DJ, Song M, Houghton PJ, et al. The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma. Genes Cancer. 2015;6(11):452-61doi: 10.18632/genesandcancer.86.
Elzi, D. J., Song, M., Houghton, P. J., Chen, Y., & Shiio, Y. (2015). The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma. Genes & cancer, 6(11), 452-61. https://doi.org/10.18632/genesandcancer.86
Elzi, David J, et al. "The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma." Genes & cancer vol. 6,11 (2015): 452-61. doi: https://doi.org/10.18632/genesandcancer.86
Elzi DJ, Song M, Houghton PJ, Chen Y, Shiio Y. The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma. Genes Cancer. 2015 Nov;6(11):452-61. doi: 10.18632/genesandcancer.86. PMID: 26807198; PMCID: PMC4701224.
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Genes Cancer. 2015 Nov;6(11):452-61. doi: 10.18632/genesandcancer.86.

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma.

Genes & cancer

David J Elzi, Meihua Song, Peter J Houghton, Yidong Chen, Yuzuru Shiio

Affiliations

  1. Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas, USA.
  2. Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas, USA; Cancer Therapy and Research Center, The University of Texas Health Science Center, San Antonio, Texas, USA; Department of Molecular Medicine, The University of Texas Health Science Center, San Antonio, Texas, USA.
  3. Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas, USA; Cancer Therapy and Research Center, The University of Texas Health Science Center, San Antonio, Texas, USA; Department of Epidemiology and Biostatistics, The University of Texas Health Science Center, San Antonio, Texas, USA.
  4. Greehey Children's Cancer Research Institute, The University of Texas Health Science Center, San Antonio, Texas, USA; Cancer Therapy and Research Center, The University of Texas Health Science Center, San Antonio, Texas, USA; Department of Biochemistry, The University of Texas Health Science Center, San Antonio, Texas, USA.

PMID: 26807198 PMCID: PMC4701224 DOI: 10.18632/genesandcancer.86

Abstract

Ewing sarcoma is a cancer of bone and soft tissue in children that is characterized by a chromosomal translocation involving EWS and an Ets family transcription factor, most commonly FLI-1. The EWS-FLI-1 fusion oncogene is widely believed to play a central role in Ewing sarcoma. The EWS-FLI-1 gene product regulates the expression of a number of genes important for cancer progression, can transform mouse cells such as NIH3T3 and C3H10T1/2, and is necessary for proliferation and tumorigenicity of Ewing sarcoma cells, suggesting that EWS-FLI-1 is the causative oncogene. However, a variety of evidence also suggest that EWS-FLI-1 alone cannot fully explain the Ewing sarcomagenesis. Here we report that FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, is frequently expressed in Ewing sarcoma. We present evidence suggesting that endogenous FLI-1-EWS is required for Ewing sarcoma growth and that FLI-1-EWS cooperates with EWS-FLI-1 in human mesenchymal stem cells, putative cells of origin of Ewing sarcoma, through abrogation of the proliferation arrest induced by EWS- FLI-1.

Keywords: EWS-FLI-1; Ewing sarcoma; FLI-1-EWS

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