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Pellegrino T, Piscopo V, Boemio A, et al. Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation. Quant Imaging Med Surg. 2015;5(6):822-8doi: 10.3978/j.issn.2223-4292.2015.11.03.
Pellegrino, T., Piscopo, V., Boemio, A., Russo, B., De Matteis, G., Pellegrino, S., Giorgio, S. M., Amato, M., Petretta, M., & Cuocolo, A. (2015). Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation. Quantitative imaging in medicine and surgery, 5(6), 822-8. https://doi.org/10.3978/j.issn.2223-4292.2015.11.03
Pellegrino, Teresa, et al. "Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation." Quantitative imaging in medicine and surgery vol. 5,6 (2015): 822-8. doi: https://doi.org/10.3978/j.issn.2223-4292.2015.11.03
Pellegrino T, Piscopo V, Boemio A, Russo B, De Matteis G, Pellegrino S, Giorgio SM, Amato M, Petretta M, Cuocolo A. Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation. Quant Imaging Med Surg. 2015 Dec;5(6):822-8. doi: 10.3978/j.issn.2223-4292.2015.11.03. PMID: 26807364; PMCID: PMC4700238.
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Quant Imaging Med Surg. 2015 Dec;5(6):822-8. doi: 10.3978/j.issn.2223-4292.2015.11.03.

Impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine indexes of cardiac sympathetic innervation.

Quantitative imaging in medicine and surgery

Teresa Pellegrino, Valentina Piscopo, Antonio Boemio, Barbara Russo, Gianluca De Matteis, Sara Pellegrino, Sara Maria Delle Acque Giorgio, Manuela Amato, Mario Petretta, Alberto Cuocolo

Affiliations

  1. 1 Institute of Biostructure and Bioimaging, National Council of Research, Via De Amicis 95, 80145 Naples, Italy ; 2 Department of Advanced Biomedical Sciences, 3 Department of Translational Medical Sciences, University Federico II, Via Pansini 5, 80131 Naples, Italy.

PMID: 26807364 PMCID: PMC4700238 DOI: 10.3978/j.issn.2223-4292.2015.11.03

Abstract

BACKGROUND: This study was designed to assess the impact of obesity and acquisition protocol on (123)I-metaiodobenzylguanidine (MIBG) indexes of cardiac sympathetic innervation.

METHODS: Forty-five patients with heart failure (HF) (38 men, age 58±15 years) underwent (123)I-MIBG cardiac imaging. Of these patients, 10 were obese [body mass index (BMI) ≥30 kg/m(2)]. Ten-minute planar images of the thorax in anterior view were performed 15 minutes ("early" image) and 3 hours and 50 minutes ("late" image) after tracer administration in both supine- and prone-position. Early and late (123)I-MIBG heart-to-mediastinum (H/M) ratios and washout rate were computed.

RESULTS: In overall study population, early and late (123)I-MIBG H/M ratios and washout rate were comparable between supine- and prone-position acquisitions. Obese patients had a lower early and late (123)I-MIBG H/M ratios both in supine (P<0.01) and prone (P<0.05) positions compared to non-obese subjects.

CONCLUSIONS: Our results indicate that in HF patients, obesity has a significant impact on (123)I-MIBG indexes of cardiac sympathetic innervation. Prone-position did not change early and late (123)I-MIBG H/M ratios and washout rate compared to supine position both in obese and non-obese HF patients.

Keywords: Metaiodobenzylguanidine cardiac imaging (MIBG cardiac imaging); heart-to-mediastinum ratios (H/M ratios); obesity; prone-position acquisition; washout rate

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