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Feldman AL. Clonal Relationships Between Malignant Lymphomas and Histiocytic/Dendritic Cell Tumors. Surg Pathol Clin. 2013;6(4):619-29doi: 10.1016/j.path.2013.08.003.
Feldman, A. L. (2013). Clonal Relationships Between Malignant Lymphomas and Histiocytic/Dendritic Cell Tumors. Surgical pathology clinics, 6(4), 619-29. https://doi.org/10.1016/j.path.2013.08.003
Feldman, Andrew L. "Clonal Relationships Between Malignant Lymphomas and Histiocytic/Dendritic Cell Tumors." Surgical pathology clinics vol. 6,4 (2013): 619-29. doi: https://doi.org/10.1016/j.path.2013.08.003
Feldman AL. Clonal Relationships Between Malignant Lymphomas and Histiocytic/Dendritic Cell Tumors. Surg Pathol Clin. 2013 Dec;6(4):619-29. doi: 10.1016/j.path.2013.08.003. Epub 2013 Sep 19. PMID: 26839189.
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Surg Pathol Clin. 2013 Dec;6(4):619-29. doi: 10.1016/j.path.2013.08.003. Epub 2013 Sep 19.

Clonal Relationships Between Malignant Lymphomas and Histiocytic/Dendritic Cell Tumors.

Surgical pathology clinics

Andrew L Feldman

Affiliations

  1. Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905, USA. Electronic address: [email protected].

PMID: 26839189 DOI: 10.1016/j.path.2013.08.003

Abstract

Tumors of histiocytic or dendritic cell origin appear to occur with increased frequency in patients with lymphoma. Recent molecular data have demonstrated clonal relationships between the lymphoma and the histiocytic/dendritic cell tumor in some of these cases. Clinical, pathologic, and experimental data suggest that this phenomenon probably represents transdifferentiation of the lymphoma clone to a histiocytic/dendritic cell lineage in most cases. Awareness of this entity is necessary to prompt comparative molecular studies in appropriate cases.

Copyright © 2013 Elsevier Inc. All rights reserved.

Keywords: Clonality; Dendritic cell tumor; Histiocytic sarcoma; Langerhans cell histiocytosis; Lineage plasticity; Transdifferentiation; Transformation

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