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Tse G, Yeo JM. Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions. Int J Cardiol Heart Vasc. 2015;9:75-82doi: 10.1016/j.ijcha.2015.10.003.
Tse, G., & Yeo, J. M. (2015). Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions. International journal of cardiology. Heart & vasculature, 975-82. https://doi.org/10.1016/j.ijcha.2015.10.003
Tse, Gary, and Yeo, Jie Ming. "Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions." International journal of cardiology. Heart & vasculature vol. 9 (2015): 75-82. doi: https://doi.org/10.1016/j.ijcha.2015.10.003
Tse G, Yeo JM. Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions. Int J Cardiol Heart Vasc. 2015 Dec 07;9:75-82. doi: 10.1016/j.ijcha.2015.10.003. PMID: 26839915; PMCID: PMC4695916.
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Int J Cardiol Heart Vasc. 2015 Dec 07;9:75-82. doi: 10.1016/j.ijcha.2015.10.003.

Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions.

International journal of cardiology. Heart & vasculature

Gary Tse, Jie Ming Yeo

Affiliations

  1. School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong.
  2. School of Medicine, Imperial College London, SW7 2AZ, UK.

PMID: 26839915 PMCID: PMC4695916 DOI: 10.1016/j.ijcha.2015.10.003

Abstract

Ventricular arrhythmias arise from disruptions in the normal orderly sequence of electrical activation and recovery of the heart. They can be categorized into disorders affecting predominantly cellular depolarization or repolarization, or those involving action potential (AP) conduction. This article briefly discusses the factors causing conduction abnormalities in the form of unidirectional conduction block and reduced conduction velocity (CV). It then examines the roles that sodium channels and gap junctions play in AP conduction. Finally, it synthesizes experimental results to illustrate molecular mechanisms of how abnormalities in these proteins contribute to such conduction abnormalities and hence ventricular arrhythmogenesis, in acquired pathologies such as acute ischaemia and heart failure, as well as inherited arrhythmic syndromes.

Keywords: Conduction; Conduction velocity; Gap junction; Sodium channel; Ventricular arrhythmia

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