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Gao L, Duan DD, Zhang JQ, et al. A Bioinformatic Approach for the Discovery of Antiaging Effects of Baicalein from Scutellaria baicalensis Georgi. Rejuvenation Res. 2016;19(5):414-422doi: 10.1089/rej.2015.1760.
Gao, L., Duan, D. D., Zhang, J. Q., Zhou, Y. Z., Qin, X. M., & Du, G. H. (2016). A Bioinformatic Approach for the Discovery of Antiaging Effects of Baicalein from Scutellaria baicalensis Georgi. Rejuvenation research, 19(5), 414-422. https://doi.org/10.1089/rej.2015.1760
Gao, Li, et al. "A Bioinformatic Approach for the Discovery of Antiaging Effects of Baicalein from Scutellaria baicalensis Georgi." Rejuvenation research vol. 19,5 (2016): 414-422. doi: https://doi.org/10.1089/rej.2015.1760
Gao L, Duan DD, Zhang JQ, Zhou YZ, Qin XM, Du GH. A Bioinformatic Approach for the Discovery of Antiaging Effects of Baicalein from Scutellaria baicalensis Georgi. Rejuvenation Res. 2016 Oct;19(5):414-422. doi: 10.1089/rej.2015.1760. Epub 2016 Mar 15. PMID: 26778291.
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Rejuvenation Res. 2016 Oct;19(5):414-422. doi: 10.1089/rej.2015.1760. Epub 2016 Mar 15.

A Bioinformatic Approach for the Discovery of Antiaging Effects of Baicalein from Scutellaria baicalensis Georgi.

Rejuvenation research

Li Gao, Dan-Dan Duan, Jian-Qin Zhang, Yu-Zhi Zhou, Xue-Mei Qin, Guan-Hua Du

Affiliations

  1. 1 Modern Research Center for Traditional Chinese Medicine, Shanxi University , Taiyuan, P.R. China .
  2. 2 College of Chemistry and Chemical Engineering, Shanxi University , Taiyuan, P.R. China .
  3. 3 Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing, P.R. China .

PMID: 26778291 DOI: 10.1089/rej.2015.1760

Abstract

Aging is one of the most complicated phenomena and is the main risk factor for age-related diseases. Based on the public aging-related gene data, we propose a computational approach to predict the antiaging activities of compounds. This approach integrates network pharmacology and target fishing methods with the aim of identifying a potential antiaging compound from Scutellaria baicalensis Georgi. Utilizing this approach and subsequent experimental validation, it was found that baicalein at concentrations of 0.04, 0.2, and 1 mg/mL extended the mean, median, and maximum life spans in Drosophila melanogaster. Particularly, 0.2 mg/mL baicalein extends the mean and median life spans in male flies by 19.80% and 25.64%, respectively. Meanwhile, it was discovered that baicalein improved fertility in flies. Baicalein exerts antiaging effects likely through attenuating oxidative stress, including increases of CAT activity and GSH level and decrease of GSSG level.

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