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Fouet M, Mader MA, Iraïn S, et al. Filter-less submicron hydrodynamic size sorting. Lab Chip. 2016;16(4):720-33doi: 10.1039/c5lc00941c.
Fouet, M., Mader, M. A., Iraïn, S., Yanha, Z., Naillon, A., Cargou, S., Gué, A. M., & Joseph, P. (2016). Filter-less submicron hydrodynamic size sorting. Lab on a chip, 16(4), 720-33. https://doi.org/10.1039/c5lc00941c
Fouet, M, et al. "Filter-less submicron hydrodynamic size sorting." Lab on a chip vol. 16,4 (2016): 720-33. doi: https://doi.org/10.1039/c5lc00941c
Fouet M, Mader MA, Iraïn S, Yanha Z, Naillon A, Cargou S, Gué AM, Joseph P. Filter-less submicron hydrodynamic size sorting. Lab Chip. 2016 Feb 21;16(4):720-33. doi: 10.1039/c5lc00941c. Epub 2016 Jan 18. PMID: 26778818.
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Lab Chip. 2016 Feb 21;16(4):720-33. doi: 10.1039/c5lc00941c. Epub 2016 Jan 18.

Filter-less submicron hydrodynamic size sorting.

Lab on a chip

M Fouet, M-A Mader, S Iraïn, Z Yanha, A Naillon, S Cargou, A-M Gué, P Joseph

Affiliations

  1. CNRS, LAAS, 7 avenue du colonel Roche, F-31400 Toulouse, France. [email protected].

PMID: 26778818 DOI: 10.1039/c5lc00941c

Abstract

We propose a simple microfluidic device able to separate submicron particles (critical size ∼0.1 μm) from a complex sample with no filter (minimum channel dimension being 5 μm) by hydrodynamic filtration. A model taking into account the actual velocity profile and hydrodynamic resistances enables prediction of the chip sorting properties for any geometry. Two design families are studied to obtain (i) small sizes within minutes (low-aspect ratio, two-level chip) and (ii) micron-sized sorting with a μL flow rate (3D architecture based on lamination). We obtain quantitative agreement of sorting performances both with experiments and with numerical solving, and determine the limits of the approach. We therefore demonstrate a passive, filter-less sub-micron size sorting with a simple, robust, and easy to fabricate design.

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