Display options
Cite
Akinlade KS, Adediji IO, Rahamon SK, et al. Serum copeptin and pregnancy outcome in preeclampsia. Niger Med J. 2015;56(5):362-8doi: 10.4103/0300-1652.170385.
Akinlade, K. S., Adediji, I. O., Rahamon, S. K., Fawole, A. O., & Tongo, O. O. (2015). Serum copeptin and pregnancy outcome in preeclampsia. Nigerian medical journal : journal of the Nigeria Medical Association, 56(5), 362-8. https://doi.org/10.4103/0300-1652.170385
Akinlade, Kehinde Sola, et al. "Serum copeptin and pregnancy outcome in preeclampsia." Nigerian medical journal : journal of the Nigeria Medical Association vol. 56,5 (2015): 362-8. doi: https://doi.org/10.4103/0300-1652.170385
Akinlade KS, Adediji IO, Rahamon SK, Fawole AO, Tongo OO. Serum copeptin and pregnancy outcome in preeclampsia. Niger Med J. 2015 Sep-Oct;56(5):362-8. doi: 10.4103/0300-1652.170385. PMID: 26778890; PMCID: PMC4698854.
Copy Download .nbib Format: NLM
Share it on

Niger Med J. 2015 Sep-Oct;56(5):362-8. doi: 10.4103/0300-1652.170385.

Serum copeptin and pregnancy outcome in preeclampsia.

Nigerian medical journal : journal of the Nigeria Medical Association

Kehinde Sola Akinlade, Isaac Oluwole Adediji, Sheu Kadiri Rahamon, Adeniran Olubukola Fawole, Olukemi Oluwatoyin Tongo

Affiliations

  1. Department of Chemical Pathology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
  2. Department of Obstetrics and Gynaecology, University of Ibadan/University College Hospital, Ibadan, Nigeria.
  3. Department of Paediatrics, University of Ibadan/University College Hospital, Ibadan, Nigeria.

PMID: 26778890 PMCID: PMC4698854 DOI: 10.4103/0300-1652.170385

Abstract

BACKGROUND: A number of biochemical predictors of preeclampsia have been reported, but little is known about their possible relationship with maternal and fetal outcomes. This study determined serum copeptin in pregnant women with preeclampsia and assessed its relationship with pregnancy outcomes.

MATERIALS AND METHODS: Thirty women with severe preeclampsia (SP), 30 with mild preeclampsia (MP), and 30 with uncomplicated pregnancy were enrolled into this study. Serum copeptin, creatinine, and liver function were determined using enzyme-linked immunosorbent assay and colorimetry as appropriate. Pregnancy outcomes, both maternal and fetal, were taken using standard methods.

RESULTS: Copeptin was significantly elevated in preeclampsia subjects compared with controls and in SP compared with MP. Assessing the diagnostic property of copeptin for preeclampsia, the area under the curve for copeptin was 0.99. Nine (30%) and 3 (10%) of SP and MP, respectively had abruptio placenta while 6 (20%), 2 (6.7%), and 1 (3.3%) still births were recorded in SP, MP, and controls, respectively. Neonates of mothers with preeclampsia had significantly lower birth weight, infant length, ponderal index, and head circumference compared with neonates of the controls. Copeptin had a significant inverse relationship with birth weight, ponderal index, head circumference, Apgar score, and infant length in neonates of mothers with preeclampsia.

CONCLUSION: Serum copeptin level in the third trimester could predict preeclampsia and its elevation is associated with adverse perinatal outcome.

Keywords: Abruptio placenta; Apgar score; copeptin; perinatal outcome; ponderal index; preeclampsia

References

  1. Eur J Obstet Gynecol Reprod Biol. 1997 Dec;75(2):115-21 - PubMed
  2. Int J Epidemiol. 1998 Apr;27(2):242-7 - PubMed
  3. Ann Afr Med. 2007 Dec;6(4):164-7 - PubMed
  4. Obstet Gynecol. 2005 Feb;105(2):402-10 - PubMed
  5. Acta Obstet Gynecol Scand. 2004 Jun;83(6):536-42 - PubMed
  6. Neuro Endocrinol Lett. 2008 Jun;29(3):341-6 - PubMed
  7. Fetal Diagn Ther. 2014;36(3):202-7 - PubMed
  8. BMC Pregnancy Childbirth. 2009 Apr 02;9:14 - PubMed
  9. Acta Obstet Gynecol Scand. 2008;87(9):953-9 - PubMed
  10. Eur J Obstet Gynecol Reprod Biol. 2003 Aug 15;109(2):153-9 - PubMed
  11. Am J Obstet Gynecol. 2000 Jul;183(1):S1-S22 - PubMed
  12. Am Fam Physician. 2001 Jul 15;64(2):263-70, 216 - PubMed
  13. Trends Endocrinol Metab. 2008 Mar;19(2):43-9 - PubMed
  14. J Obstet Gynaecol Res. 2011 Sep;37(9):1198-202 - PubMed
  15. Lancet. 2010 Aug 21;376(9741):631-44 - PubMed
  16. Reprod Sci. 2008 Nov;15(9):939-49 - PubMed

Publication Types