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Seirafi M, De Weerd P, Pegna AJ, et al. Audiovisual Association Learning in the Absence of Primary Visual Cortex. Front Hum Neurosci. 2016;9:686doi: 10.3389/fnhum.2015.00686.
Seirafi, M., De Weerd, P., Pegna, A. J., & de Gelder, B. (2015). Audiovisual Association Learning in the Absence of Primary Visual Cortex. Frontiers in human neuroscience, 9686. https://doi.org/10.3389/fnhum.2015.00686
Seirafi, Mehrdad, et al. "Audiovisual Association Learning in the Absence of Primary Visual Cortex." Frontiers in human neuroscience vol. 9 (2015): 686. doi: https://doi.org/10.3389/fnhum.2015.00686
Seirafi M, De Weerd P, Pegna AJ, de Gelder B. Audiovisual Association Learning in the Absence of Primary Visual Cortex. Front Hum Neurosci. 2016 Jan 05;9:686. doi: 10.3389/fnhum.2015.00686. eCollection 2015. PMID: 26778999; PMCID: PMC4700202.
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Front Hum Neurosci. 2016 Jan 05;9:686. doi: 10.3389/fnhum.2015.00686. eCollection 2015.

Audiovisual Association Learning in the Absence of Primary Visual Cortex.

Frontiers in human neuroscience

Mehrdad Seirafi, Peter De Weerd, Alan J Pegna, Beatrice de Gelder

Affiliations

  1. Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University Maastricht, Netherlands.
  2. Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht UniversityMaastricht, Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud UniversityNijmegen, Netherlands.
  3. Department of Neurology, Geneva University Hospital Geneva, Switzerland.

PMID: 26778999 PMCID: PMC4700202 DOI: 10.3389/fnhum.2015.00686

Abstract

Learning audiovisual associations is mediated by the primary cortical areas; however, recent animal studies suggest that such learning can take place even in the absence of the primary visual cortex. Other studies have demonstrated the involvement of extra-geniculate pathways and especially the superior colliculus (SC) in audiovisual association learning. Here, we investigated such learning in a rare human patient with complete loss of the bilateral striate cortex. We carried out an implicit audiovisual association learning task with two different colors of red and purple (the latter color known to minimally activate the extra-genicular pathway). Interestingly, the patient learned the association between an auditory cue and a visual stimulus only when the unseen visual stimulus was red, but not when it was purple. The current study presents the first evidence showing the possibility of audiovisual association learning in humans with lesioned striate cortex. Furthermore, in line with animal studies, it supports an important role for the SC in audiovisual associative learning.

Keywords: audiovisual learning; blindsight; superior colliculus

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