Display options
Cite
Khan D, Ansar Ahmed S. The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases. Front Immunol. 2016;6:635doi: 10.3389/fimmu.2015.00635.
Khan, D., & Ansar Ahmed, S. (2015). The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases. Frontiers in immunology, 6635. https://doi.org/10.3389/fimmu.2015.00635
Khan, Deena, and Ansar Ahmed, S. "The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases." Frontiers in immunology vol. 6 (2015): 635. doi: https://doi.org/10.3389/fimmu.2015.00635
Khan D, Ansar Ahmed S. The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases. Front Immunol. 2016 Jan 06;6:635. doi: 10.3389/fimmu.2015.00635. eCollection 2015. PMID: 26779182; PMCID: PMC4701921.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2016 Jan 06;6:635. doi: 10.3389/fimmu.2015.00635. eCollection 2015.

The Immune System Is a Natural Target for Estrogen Action: Opposing Effects of Estrogen in Two Prototypical Autoimmune Diseases.

Frontiers in immunology

Deena Khan, S Ansar Ahmed

Affiliations

  1. Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech , Blacksburg, VA , USA.

PMID: 26779182 PMCID: PMC4701921 DOI: 10.3389/fimmu.2015.00635

Abstract

Analogous to other physiological systems, the immune system also demonstrates remarkable sex differences. Although the reasons for sex differences in immune responses are not precisely understood, it potentially involves differences in sex hormones (estrogens, androgens, and differential sex hormone receptor-mediated events), X-chromosomes, microbiome, epigenetics among others. Overall, females tend to have more responsive and robust immune system compared to their male counterparts. It is therefore not surprising that females respond more aggressively to self-antigens and are more susceptible to autoimmune diseases. Female hormone (estrogen or 17β-estradiol) can potentially act on all cellular subsets of the immune system through estrogen receptor-dependent and -independent mechanisms. This minireview highlights differential expression of estrogen receptors on immune cells, major estrogen-mediated signaling pathways, and their effect on immune cells. Since estrogen has varied effects in female-predominant autoimmune diseases such as multiple sclerosis and systemic lupus erythematosus, we will mechanistically postulate the potential differential role of estrogen in these chronic debilitating diseases.

Keywords: MS; SLE; autoimmune; estrogen; immune cell; signaling

References

  1. J Leukoc Biol. 2007 Oct;82(4):1019-26 - PubMed
  2. J Immunol. 2011 Sep 1;187(5):2386-93 - PubMed
  3. J Biomed Biotechnol. 2010;2010:317452 - PubMed
  4. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1497-502 - PubMed
  5. Biol Sex Differ. 2013 Nov 01;4(1):19 - PubMed
  6. J Neurosci Res. 2001 Sep 15;65(6):529-42 - PubMed
  7. Mol Aspects Med. 2006 Aug;27(4):299-402 - PubMed
  8. J Neuroimmunol. 2011 Jan;230(1-2):105-13 - PubMed
  9. J Clin Invest. 2002 Jun;109(12):1625-33 - PubMed
  10. Science. 2013 Mar 1;339(6123):1084-8 - PubMed
  11. J Immunol. 1999 Oct 15;163(8):4168-74 - PubMed
  12. Nat Immunol. 2005 Jan;6(1):90-8 - PubMed
  13. Steroids. 2004 Sep;69(10):653-9 - PubMed
  14. Clin Exp Immunol. 1996 Oct;106(1):127-33 - PubMed
  15. Am J Reprod Immunol. 2001 Oct;46(4):298-307 - PubMed
  16. Am J Pathol. 2003 Oct;163(4):1599-605 - PubMed
  17. Am J Med. 1994 May;96(5):457-62 - PubMed
  18. J Hum Genet. 2011 Jul;56(7):503-7 - PubMed
  19. J Leukoc Biol. 2007 Sep;82(3):774-80 - PubMed
  20. SOJ Immunol. 2014 Jan 20;2(1):null - PubMed
  21. Thymus. 1992 Sep;20(2):115-21 - PubMed
  22. Science. 1995 Dec 1;270(5241):1491-4 - PubMed
  23. Int Immunopharmacol. 2015 Jan;24(1):24-35 - PubMed
  24. Transl Res. 2011 Jun;157(6):326-31 - PubMed
  25. J Reprod Immunol. 2001 Oct-Nov;52(1-2):113-27 - PubMed
  26. Clin Immunol. 2010 Feb;134(2):226-36 - PubMed
  27. Nat Rev Cancer. 2011 Jul 22;11(8):597-608 - PubMed
  28. Endocr Rev. 2007 Aug;28(5):521-74 - PubMed
  29. Cell Immunol. 2013 Sep-Oct;285(1-2):133-40 - PubMed
  30. N Engl J Med. 1998 Jul 30;339(5):285-91 - PubMed
  31. J Allergy Clin Immunol. 1999 Feb;103(2 Pt 1):282-8 - PubMed
  32. J Bone Miner Res. 1999 Jun;14(6):923-9 - PubMed
  33. Arthritis Rheum. 2011 Mar;63(3):738-48 - PubMed
  34. J Neurosci Res. 2002 Oct 15;70(2):238-48 - PubMed
  35. Shock. 2008 Mar;29(3):362-71 - PubMed
  36. Lupus. 2004;13(4):217-22 - PubMed
  37. Immunology. 2000 Jul;100(3):384-90 - PubMed
  38. J Neurosci. 2013 Jun 26;33(26):10924-33 - PubMed
  39. Nitric Oxide. 2006 Nov;15(3):177-86 - PubMed
  40. J Clin Endocrinol Metab. 1997 Oct;82(10):3509-12 - PubMed
  41. Clin Rheumatol. 2007 Oct;26(10):1675-8 - PubMed
  42. J Immunol. 2005 Nov 1;175(9):5716-23 - PubMed
  43. Lupus. 2002;11(10):662-6 - PubMed
  44. J Neuroimmunol. 2004 Nov;156(1-2):58-65 - PubMed
  45. N Engl J Med. 1994 Oct 20;331(16):1056-61 - PubMed
  46. Endocrinology. 2009 Mar;150(3):1310-20 - PubMed
  47. J Reprod Immunol. 2008 Jun;78(1):11-21 - PubMed
  48. Immunol Lett. 2005 Feb 15;97(1):107-13 - PubMed
  49. Arch Immunol Ther Exp (Warsz). 2003;51(3):185-93 - PubMed
  50. Mol Immunol. 2007 Mar;44(7):1808-14 - PubMed
  51. Cell Immunol. 2015 Apr;294(2):63-9 - PubMed
  52. Mol Biol Rep. 2014 Sep;41(9):5755-63 - PubMed
  53. Clin Exp Rheumatol. 2009 Mar-Apr;27(2):260-6 - PubMed
  54. J Immunol. 1991 Jun 15;146(12):4362-7 - PubMed
  55. Neuro Endocrinol Lett. 2003 Jun-Aug;24(3-4):185-91 - PubMed
  56. J Immunol. 2004 Aug 15;173(4):2227-30 - PubMed
  57. Ann Rheum Dis. 2004 Oct;63(10):1244-9 - PubMed
  58. Mol Immunol. 2013 Dec;56(4):328-39 - PubMed
  59. Am J Pathol. 1985 Dec;121(3):531-51 - PubMed
  60. Clin Immunol. 2007 May;123(2):219-26 - PubMed
  61. J Cell Physiol. 2008 Feb;214(2):456-64 - PubMed
  62. J Immunol. 2006 Mar 1;176(5):2703-10 - PubMed
  63. Int Immunopharmacol. 2001 Jun;1(6):1025-35 - PubMed
  64. Blood. 2008 Dec 1;112(12):4591-7 - PubMed
  65. Ther Adv Neurol Disord. 2013 Jul;6(4):237-48 - PubMed
  66. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19125-30 - PubMed
  67. J Virol. 2014 May;88(9):4711-20 - PubMed
  68. Ann N Y Acad Sci. 2006 Nov;1089:343-72 - PubMed
  69. Eur J Immunol. 2014 May;44(5):1503-16 - PubMed
  70. Menopause. 2014 Jul;21(7):749-52 - PubMed
  71. Int Immunopharmacol. 2008 May;8(5):654-60 - PubMed
  72. Immunol Rev. 2009 May;229(1):244-58 - PubMed
  73. J Immunol. 2008 Jan 15;180(2):727-38 - PubMed
  74. J Neurosci Res. 2012 Jul;90(7):1310-23 - PubMed
  75. Mol Med. 2011 Mar-Apr;17(3-4):211-20 - PubMed
  76. Horm Behav. 2012 Aug;62(3):254-62 - PubMed
  77. Eur J Immunol. 2003 Feb;33(2):512-21 - PubMed
  78. Cytokine. 2001 May 21;14(4):208-17 - PubMed
  79. Trends Pharmacol Sci. 2003 Sep;24(9):479-85 - PubMed
  80. Int Immunol. 2007 Mar;19(3):337-43 - PubMed
  81. J Immunol. 1998 Jul 1;161(1):27-34 - PubMed
  82. Gend Med. 2004 Aug;1(1):12-7 - PubMed
  83. J Neuroimmunol. 2005 Dec 30;170(1-2):85-92 - PubMed
  84. J Immunol. 2009 Apr 1;182(7):4406-14 - PubMed
  85. J Immunol. 2011 Mar 15;186(6):3346-55 - PubMed
  86. Brain. 2004 Jun;127(Pt 6):1353-60 - PubMed
  87. Cell Immunol. 1998 Nov 1;189(2):125-34 - PubMed
  88. Lupus. 2004;13(9):635-8 - PubMed
  89. Curr Genomics. 2014 Feb;15(1):52-65 - PubMed
  90. J Am Soc Nephrol. 2014 Dec;25(12):2859-70 - PubMed
  91. J Immunol. 2011 May 1;186(9):5304-12 - PubMed
  92. Immunology. 2001 May;103(1):17-25 - PubMed
  93. Cell Immunol. 2015 Apr;294(2):70-9 - PubMed
  94. Am J Reprod Immunol. 1995 May;33(5):381-93 - PubMed
  95. N Engl J Med. 1997 Jul 10;337(2):91-5 - PubMed
  96. J Mol Cell Biol. 2010 Oct;2(5):284-90 - PubMed
  97. Autoimmunity. 2008 May;41(4):287-97 - PubMed
  98. Immunity. 2013 Aug 22;39(2):400-12 - PubMed
  99. Immunol Lett. 2008 Aug 15;119(1-2):32-41 - PubMed
  100. Immun Inflamm Dis. 2014 Dec;2(4):214-25 - PubMed
  101. J Immunol. 2014 Dec 1;193(11):5444-52 - PubMed
  102. Respir Res. 2010 Nov 30;11:166 - PubMed
  103. Proc Natl Acad Sci U S A. 2004 Feb 10;101(6):1720-4 - PubMed
  104. Ann Rheum Dis. 2005 Nov;64(11):1611-7 - PubMed
  105. J Leukoc Biol. 2004 Jun;75(6):1166-72 - PubMed
  106. Blood. 2003 Dec 1;102(12):4084-9 - PubMed
  107. Int J Neurosci. 1990 Apr;51(3-4):315-7 - PubMed
  108. Arch Histol Cytol. 1997 Mar;60(1):29-38 - PubMed
  109. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15677-82 - PubMed

Publication Types