Display options
Cite
Park HY, Lee SH, Lee KS, et al. Ginsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells. Immune Netw. 2015;15(6):331-6doi: 10.4110/in.2015.15.6.331.
Park, H. Y., Lee, S. H., Lee, K. S., Yoon, H. K., Yoo, Y. C., Lee, J., Choi, J. E., Kim, P. H., & Park, S. R. (2015). Ginsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells. Immune network, 15(6), 331-6. https://doi.org/10.4110/in.2015.15.6.331
Park, Ha-Yan, et al. "Ginsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells." Immune network vol. 15,6 (2015): 331-6. doi: https://doi.org/10.4110/in.2015.15.6.331
Park HY, Lee SH, Lee KS, Yoon HK, Yoo YC, Lee J, Choi JE, Kim PH, Park SR. Ginsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells. Immune Netw. 2015 Dec;15(6):331-6. doi: 10.4110/in.2015.15.6.331. Epub 2015 Dec 24. PMID: 26770188; PMCID: PMC4700410.
Copy Download .nbib Format: NLM
Share it on

Immune Netw. 2015 Dec;15(6):331-6. doi: 10.4110/in.2015.15.6.331. Epub 2015 Dec 24.

Ginsenoside Rg1 and 20(S)-Rg3 Induce IgA Production by Mouse B Cells.

Immune network

Ha-Yan Park, Sang-Hoon Lee, Kyu-Seon Lee, Hee-Kyung Yoon, Yung-Choon Yoo, Junglim Lee, Jae Eul Choi, Pyeung-Hyeun Kim, Seok-Rae Park

Affiliations

  1. Department of Microbiology, College of Medicine, Konyang University, Daejeon 35365, Korea.; Myunggok Medical Research Institute, College of Medicine, Konyang University, Daejeon 35365, Korea.
  2. College of Agriculture and Life Science, Chungnam National University, Daejeon 34134, Korea.
  3. Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea.

PMID: 26770188 PMCID: PMC4700410 DOI: 10.4110/in.2015.15.6.331

Abstract

Ginsenosides are the major components of ginseng, which is known to modulate blood pressure, metabolism, and immune function, and has been used to treat various diseases. It has been reported that ginseng and several ginsenosides have immunoregulatory effects on the innate and T cell-mediated immune response. However, their effects on the humoral immune response have not been fully explored. The present study examined the direct effects of red ginseng extract (RGE) and ginsenosides on mouse B cell proliferation and on antibody production and the expression of germline transcripts (GLT) by mouse B cells in vitro. RGE slightly reduced B cell proliferation, but increased IgA production by LPS-stimulated B cells. Furthermore, ginsenoside Rg1 and 20(S)-Rg3 selectively induced IgA production and expression of GLTα transcripts by LPS-stimulated B cells. Collectively, these results suggest that ginsenoside Rg1 and 20(S)-Rg3 can drive the differentiation of B cells into IgA-producing cells through the selective induction of GLTα expression.

Keywords: B cells; Germline α transcripts; Ginseng; Ginsenoside; IgA

References

  1. Clin Vaccine Immunol. 2008 Feb;15(2):303-7 - PubMed
  2. Curr Opin Immunol. 1996 Apr;8(2):199-205 - PubMed
  3. Immune Netw. 2012 Jun;12(3):89-95 - PubMed
  4. J Ginseng Res. 2014 Apr;38(2):146-53 - PubMed
  5. Biomedicine. 1979 Dec;31(8):223-7 - PubMed
  6. Int Immunopharmacol. 2011 Apr;11(4):511-8 - PubMed
  7. J Ethnopharmacol. 2008 Feb 28;116(1):179-86 - PubMed
  8. Acta Pharmacol Sin. 2008 Sep;29(9):1109-18 - PubMed
  9. Vaccine. 2007 Jan 2;25(1):161-9 - PubMed
  10. Int Immunopharmacol. 2014 Nov;23 (1):77-84 - PubMed
  11. Int Immunopharmacol. 2014 Jun;20(2):283-9 - PubMed
  12. Int Immunopharmacol. 2010 May;10(5):626-31 - PubMed
  13. Int Immunopharmacol. 2012 Dec;14 (4):481-6 - PubMed
  14. Int Immunopharmacol. 2006 Sep;6(9):1424-30 - PubMed
  15. Curr Top Microbiol Immunol. 2000;245(2):127-68 - PubMed
  16. Vet Parasitol. 2011 Jun 30;179(1-3):28-34 - PubMed
  17. Vaccine. 2012 Jun 8;30(27):4106-12 - PubMed
  18. Int Immunopharmacol. 2004 Feb;4(2):235-44 - PubMed
  19. Int Immunol. 2012 Jul;24(7):465-71 - PubMed
  20. Cytokine. 2013 Feb;61(2):608-13 - PubMed
  21. Proc Natl Acad Sci U S A. 1990 May;87(10):3962-6 - PubMed
  22. Vaccine. 2005 Nov 16;23 (46-47):5411-9 - PubMed
  23. Biochem Pharmacol. 1999 Dec 1;58(11):1685-93 - PubMed
  24. Int Immunopharmacol. 2008 Aug;8(8):1134-42 - PubMed
  25. J Exp Med. 1993 Apr 1;177(4):1031-7 - PubMed
  26. Chin Med. 2010 Jun 11;5:20 - PubMed
  27. J Ethnopharmacol. 1992 Feb;36(1):27-38 - PubMed
  28. Chin Med. 2007 May 15;2:6 - PubMed
  29. Int Immunopharmacol. 2013 Nov;17 (3):651-7 - PubMed
  30. Biochem Pharmacol. 1997 Jul 1;54(1):1-8 - PubMed
  31. Curr Med Chem. 2009;16(19):2475-84 - PubMed
  32. Int Immunopharmacol. 2010 Mar;10(3):351-6 - PubMed
  33. Altern Med Rev. 2006 Jun;11(2):128-50 - PubMed

Publication Types