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Takeda K, Kudo SE, Mori Y, et al. Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum. Oncol Lett. 2015;11(1):237-242doi: 10.3892/ol.2015.3910.
Takeda, K., Kudo, S. E., Mori, Y., Misawa, M., Kudo, T., Wakamura, K., Hayashi, T., Miyachi, H., Ishida, F., & Inoue, H. (2016). Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum. Oncology letters, 11(1), 237-242. https://doi.org/10.3892/ol.2015.3910
Takeda, Kenichi, et al. "Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum." Oncology letters vol. 11,1 (2016): 237-242. doi: https://doi.org/10.3892/ol.2015.3910
Takeda K, Kudo SE, Mori Y, Misawa M, Kudo T, Wakamura K, Hayashi T, Miyachi H, Ishida F, Inoue H. Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum. Oncol Lett. 2016 Jan;11(1):237-242. doi: 10.3892/ol.2015.3910. Epub 2015 Nov 10. PMID: 26870195; PMCID: PMC4726939.
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Oncol Lett. 2016 Jan;11(1):237-242. doi: 10.3892/ol.2015.3910. Epub 2015 Nov 10.

Magnifying chromoendoscopic and endocytoscopic findings of juvenile polyps in the colon and rectum.

Oncology letters

Kenichi Takeda, Shin-Ei Kudo, Yuichi Mori, Masashi Misawa, Toyoki Kudo, Kunihiko Wakamura, Takemasa Hayashi, Hideyuki Miyachi, Fumio Ishida, Haruhiro Inoue

Affiliations

  1. Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224-8503, Japan.
  2. Digestive Disease Center, Showa University Koto-Toyosu Hospital, Tokyo 135-8577, Japan.

PMID: 26870195 PMCID: PMC4726939 DOI: 10.3892/ol.2015.3910

Abstract

A precise endoscopic diagnosis is necessary for endoscopic therapy for neoplastic and non-neoplastic lesions, including juvenile polyps (JPs). Therefore, the present study aimed to clarify the characteristic endoscopic findings of JPs. A total of 154 JPs were evaluated by magnifying chromoendoscopy, 20 of which were also assessed by endocytoscopy using an ultra-high magnification endoscope. Endoscopic images were evaluated in terms of gross appearance, color, pit pattern, surface inflammatory changes and vascularity of polyps. Endocytoscopic images were evaluated with regard to the morphology of glandular cavities, nuclei of glandular cells and interstitial features. Reddish surfaces (98.1%), surface erosion (92.2%), open pits (90.3%) and low pit density (90.3%) were observed in the majority of JPs by chromoendoscopy. In addition, dilated ductal openings surrounded by normal glandular cells (100%), greater distances between gland basal layers (100%) and interstitial infiltration by inflammatory cells (100%) were observed in all JPs examined by endocytoscopy. These findings indicate that there is a tetralogy of magnifying chromoendoscopic findings characteristic of JPs: Reddish surfaces, surface erosion, open pits and low pit density. There is also a triad of endocytoscopic findings characteristic of JPs, namely dilated ductal openings surrounded by normal glandular cells, greater distances between gland basal layers, and interstitial infiltration by inflammatory cells. The aforementioned magnifying chromoendoscopic and endocytoscopic characteristics of JPs may be useful factors for diagnosing JPs.

Keywords: advanced endoscopy; endocytoscopy; juvenile polyp; magnifying chromoendoscopy; ultra-high magnification

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