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Guo CX, Wang J, Huang LH, et al. Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients. Mol Clin Oncol. 2015;4(1):3-10doi: 10.3892/mco.2015.666.
Guo, C. X., Wang, J., Huang, L. H., Li, J. G., & Chen, X. (2016). Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients. Molecular and clinical oncology, 4(1), 3-10. https://doi.org/10.3892/mco.2015.666
Guo, Cheng-Xian, et al. "Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients." Molecular and clinical oncology vol. 4,1 (2016): 3-10. doi: https://doi.org/10.3892/mco.2015.666
Guo CX, Wang J, Huang LH, Li JG, Chen X. Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients. Mol Clin Oncol. 2016 Jan;4(1):3-10. doi: 10.3892/mco.2015.666. Epub 2015 Oct 30. PMID: 26870349; PMCID: PMC4727127.
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Mol Clin Oncol. 2016 Jan;4(1):3-10. doi: 10.3892/mco.2015.666. Epub 2015 Oct 30.

Impact of single-nucleotide polymorphisms on radiation pneumonitis in cancer patients.

Molecular and clinical oncology

Cheng-Xian Guo, Jing Wang, Li-Hua Huang, Jin-Gao Li, Xiang Chen

Affiliations

  1. Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
  2. Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China; Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China.
  3. Center for Experimental Medical Research, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China.
  4. Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China.
  5. Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China.

PMID: 26870349 PMCID: PMC4727127 DOI: 10.3892/mco.2015.666

Abstract

Radiation pneumonitis (RP) is one of the most important dose-limiting toxicities in the radiotherapy of thoracic tumors, which reduces the rate of local tumor control and overall survival and severely affects the patients' quality of life. Single-nucleotide polymorphisms (SNPs) have recently attracted increasing attention as biomarkers for predicting the development of RP. SNPs in inflammation-related, DNA repair-related, stress response-related and angiogenesis-related genes were proved to be associated with RP, with different underlying mechanisms. Radiogenomics focuses on the differences in radiosensitivity caused by gene sequence variation, which may prove helpful in investigating the abovementioned associations. In this review, we aimed to investigate the associations between RP and SNPs reported in recent studies and highlight the main content and prospects of radiogenomics.

Keywords: genetic markers; radiation pneumonitis; single-nucleotide polymorphisms

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