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Ibraheem ZO, Abdul Majid R, Mohd Noor S, et al. The Potential of β Carbolin Alkaloids to Hinder Growth and Reverse Chloroquine Resistance in Plasmodium falciparum. Iran J Parasitol. 2015;10(4):577-83
Ibraheem, Z. O., Abdul Majid, R., Mohd Noor, S., Mohd Sidek, H., & Basir, R. (2015). The Potential of β Carbolin Alkaloids to Hinder Growth and Reverse Chloroquine Resistance in Plasmodium falciparum. Iranian journal of parasitology, 10(4), 577-83.
Ibraheem, Zaid O, et al. "The Potential of β Carbolin Alkaloids to Hinder Growth and Reverse Chloroquine Resistance in Plasmodium falciparum." Iranian journal of parasitology vol. 10,4 (2015): 577-83.
Ibraheem ZO, Abdul Majid R, Mohd Noor S, Mohd Sidek H, Basir R. The Potential of β Carbolin Alkaloids to Hinder Growth and Reverse Chloroquine Resistance in Plasmodium falciparum. Iran J Parasitol. 2015 Oct-Dec;10(4):577-83. PMID: 26811724; PMCID: PMC4724834.
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Iran J Parasitol. 2015 Oct-Dec;10(4):577-83.

The Potential of β Carbolin Alkaloids to Hinder Growth and Reverse Chloroquine Resistance in Plasmodium falciparum.

Iranian journal of parasitology

Zaid O Ibraheem, Roslaini Abdul Majid, Sabariah Mohd Noor, Hasidah Mohd Sidek, Rusliza Basir

Affiliations

  1. Pharmacology Unit, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
  2. Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
  3. Department of Hematology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia.
  4. School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, UKM-Bangi, Selangor, Malaysia.

PMID: 26811724 PMCID: PMC4724834

Abstract

BACKGROUND: Nowadays, scourge of malaria as a fatalistic disease has increased due to emergence of drug resistance and tolerance among different strains of Plasmodium falciparum. Emergence of chloroquine (CQ) resistance has worsened the calamity as CQ is still considered the most efficient, safe and cost effective drug among other antimalarials. This urged the scientists to search for other alternatives or sensitizers that may be able to augment CQ action and reverse its resistance.

METHOD: Three β-carbolin derivatives, namely, harmalin, harmol and harmalol were tested for their anti-plasmodial and CQ resistance reversal effects against P. falciparum 3D7 and K1. SYBRE Green-1 based drug sensitivity assay and isobologram analysis were used to screen the mentioned effects respectively.

RESULTS: All of them showed moderate anti-plasmodium effect and harmalin was the most effective as compared to the others in reversing CQ resistance and tolerance.

CONCLUSION: The mentioned phytochemicals are not ideal to be used as conventional antimalarials and only harmalin can be suggested to reverse CQ resistance in P. falciparum K1.

Keywords: Chloroquine; Isobologram; Resistance; SYBR green-I; falciparum; β-carbolin

References

  1. PLoS Pathog. 2010 May 13;6(5):e1000887 - PubMed
  2. J Pharm Pharm Sci. 2002 Jan-Apr;5(1):19-23 - PubMed
  3. Cell Death Dis. 2011 Oct 13;2:e216 - PubMed
  4. Drug Resist Updat. 2009 Feb-Apr;12(1-2):42-50 - PubMed
  5. Trans R Soc Trop Med Hyg. 1997 May-Jun;91(3):363-5 - PubMed
  6. Am J Trop Med Hyg. 2010 Mar;82(3):398-401 - PubMed
  7. Mutat Res. 1997 Oct 6;379(2):135-49 - PubMed
  8. Curr Med Chem. 2007;14(4):479-500 - PubMed
  9. Science. 1976 Aug 20;193(4254):673-5 - PubMed
  10. Biochem J. 1986 Jan 15;233(2):607-11 - PubMed
  11. Mutat Res. 1996 Feb 1;349(2):183-91 - PubMed
  12. Exp Toxicol Pathol. 2008 Aug;60(4-5):381-9 - PubMed
  13. Cancer Lett. 1983 Jan;17 (3):249-55 - PubMed
  14. Chin Med. 2011 Mar 23;6(1):11 - PubMed
  15. Int J Cancer. 2005 May 1;114(5):675-82 - PubMed
  16. Curr Drug Targets. 2006 Aug;7(8):935-48 - PubMed
  17. J Parasitol. 1979 Jun;65(3):418-20 - PubMed
  18. Am J Trop Med Hyg. 2001 Jan-Feb;64(1-2 Suppl):12-7 - PubMed
  19. Antimicrob Agents Chemother. 2002 Sep;46(9):2889-94 - PubMed
  20. Pharmacol Toxicol. 2001 Dec;89(6):287-94 - PubMed
  21. Bioorg Med Chem Lett. 2002 Apr 8;12 (7):1129-32 - PubMed
  22. Mutat Res. 1993 Jul;302(3):165-71 - PubMed
  23. Antimicrob Agents Chemother. 2004 Nov;48(11):4097-102 - PubMed

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