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Fujii K, Nitta T, Kawasaki H, et al. Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report. Mol Clin Oncol. 2015;4(1):39-42doi: 10.3892/mco.2015.671.
Fujii, K., Nitta, T., Kawasaki, H., Kataoka, J., Tominaga, T., Inoue, Y., Kadota, E., Ishibashi, T., & Uchiyama, K. (2016). Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report. Molecular and clinical oncology, 4(1), 39-42. https://doi.org/10.3892/mco.2015.671
Fujii, Kensuke, et al. "Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report." Molecular and clinical oncology vol. 4,1 (2016): 39-42. doi: https://doi.org/10.3892/mco.2015.671
Fujii K, Nitta T, Kawasaki H, Kataoka J, Tominaga T, Inoue Y, Kadota E, Ishibashi T, Uchiyama K. Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report. Mol Clin Oncol. 2016 Jan;4(1):39-42. doi: 10.3892/mco.2015.671. Epub 2015 Nov 09. PMID: 26870354; PMCID: PMC4727070.
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Mol Clin Oncol. 2016 Jan;4(1):39-42. doi: 10.3892/mco.2015.671. Epub 2015 Nov 09.

Anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm: A case report.

Molecular and clinical oncology

Kensuke Fujii, Toshikatsu Nitta, Hiroshi Kawasaki, Jun Kataoka, Tomo Tominaga, Yoshihiro Inoue, Eiji Kadota, Takashi Ishibashi, Kazuhisa Uchiyama

Affiliations

  1. Department of Gastroenterological Surgery, Shiroyama Hospital, Habikino, Osaka 583-0872, Japan.
  2. Department of General and Gastroenterological Surgery, Osaka Medical College Hospital, Takatsuki, Osaka 569-0801, Japan.
  3. Division of Pathology, Japan Clinical Laboratories, Inc., Moriguchi, Osaka 570-0033, Japan.

PMID: 26870354 PMCID: PMC4727070 DOI: 10.3892/mco.2015.671

Abstract

We herein report a case of anaplastic carcinoma of the pancreas arising in an intraductal papillary mucinous neoplasm (IPMN). A 68-year-old Japanese woman was admitted to our hospital complaining of fatigue. Computed tomography revealed an irregular mass in the pancreatic head, which displayed high-signal intensity on diffusion-weighted magnetic resonance imaging. Accordingly, the patient was diagnosed with pancreatic cancer and underwent pancreaticoduodenectomy. The histopathological findings revealed intraductal papillary proliferative changes involving the main and branch ducts of the pancreatic head. Based on the immunohistochemistry results, the intraductal lesion was diagnosed as IPMN. The pathological diagnosis for the invasive carcinoma was anaplastic giant-cell carcinoma of the pancreas (ACP), and the focus of IPMN dedifferentiation to ACP was found to be located at the periphery of the IPMN. At 18 months postoperatively, the patient remains disease-free.

Keywords: anaplastic carcinoma; intraductal papillary mucinous neoplasm

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