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Mehta RS, Shpall EJ, Rezvani K. Cord Blood as a Source of Natural Killer Cells. Front Med (Lausanne). 2016;2:93doi: 10.3389/fmed.2015.00093.
Mehta, R. S., Shpall, E. J., & Rezvani, K. (2015). Cord Blood as a Source of Natural Killer Cells. Frontiers in medicine, 293. https://doi.org/10.3389/fmed.2015.00093
Mehta, Rohtesh S, et al. "Cord Blood as a Source of Natural Killer Cells." Frontiers in medicine vol. 2 (2015): 93. doi: https://doi.org/10.3389/fmed.2015.00093
Mehta RS, Shpall EJ, Rezvani K. Cord Blood as a Source of Natural Killer Cells. Front Med (Lausanne). 2016 Jan 05;2:93. doi: 10.3389/fmed.2015.00093. eCollection 2015. PMID: 26779484; PMCID: PMC4700256.
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Front Med (Lausanne). 2016 Jan 05;2:93. doi: 10.3389/fmed.2015.00093. eCollection 2015.

Cord Blood as a Source of Natural Killer Cells.

Frontiers in medicine

Rohtesh S Mehta, Elizabeth J Shpall, Katayoun Rezvani

Affiliations

  1. Division of Hematology, Oncology and Transplantation, University of Minnesota Medical Center , Minneapolis, MN , USA.
  2. Department of Stem Cell Transplantation, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center , Houston, TX , USA.

PMID: 26779484 PMCID: PMC4700256 DOI: 10.3389/fmed.2015.00093

Abstract

Cord blood (CB) offers several unique advantages as a graft source for hematopoietic stem cell transplantation (HSCT). The risk of relapse and graft vs. host disease after cord blood transplantation (CBT) is lower than what is typically observed after other graft sources with a similar degree of human leukocyte antigen mismatch. Natural killer (NK) cells have a well-defined role in both innate and adaptive immunity and as the first lymphocytes to reconstitute after HSCT and CBT, and they play a significant role in protection against early relapse. In this article, we highlight the uses of CB NK cells in transplantation and adoptive immunotherapy. First, we will describe differences in the phenotype and functional characteristics of NK cells in CB as compared with peripheral blood. Then, we will review some of the obstacles we face in using resting CB NK cells for adoptive immunotherapy, and discuss methods to overcome them. We will review the current literature on killer-cell immunoglobulin-like receptors ligand mismatch and outcomes after CBT. Finally, we will touch on current strategies for the use of CB NK cells in cellular immunotherapy.

Keywords: CBT; KIR mismatch; adoptive immunotherapy; cord blood; natural killer cells; transplantation

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