Display options
Cite
Carr BJ, Canapp SO, Mason DR, et al. Canine Platelet-Rich Plasma Systems: A Prospective Analysis. Front Vet Sci. 2016;2:73doi: 10.3389/fvets.2015.00073.
Carr, B. J., Canapp, S. O., Mason, D. R., Cox, C., & Hess, T. (2015). Canine Platelet-Rich Plasma Systems: A Prospective Analysis. Frontiers in veterinary science, 273. https://doi.org/10.3389/fvets.2015.00073
Carr, Brittany Jean, et al. "Canine Platelet-Rich Plasma Systems: A Prospective Analysis." Frontiers in veterinary science vol. 2 (2015): 73. doi: https://doi.org/10.3389/fvets.2015.00073
Carr BJ, Canapp SO, Mason DR, Cox C, Hess T. Canine Platelet-Rich Plasma Systems: A Prospective Analysis. Front Vet Sci. 2016 Jan 05;2:73. doi: 10.3389/fvets.2015.00073. eCollection 2015. PMID: 26779493; PMCID: PMC4700921.
Copy Download .nbib Format: NLM
Share it on

Front Vet Sci. 2016 Jan 05;2:73. doi: 10.3389/fvets.2015.00073. eCollection 2015.

Canine Platelet-Rich Plasma Systems: A Prospective Analysis.

Frontiers in veterinary science

Brittany Jean Carr, Sherman O Canapp, David R Mason, Catherine Cox, Theresa Hess

Affiliations

  1. Veterinary Orthopedic and Sports Medicine , Annapolis Junction, MD , USA.
  2. Las Vegas Veterinary Specialty Center , Las Vegas, NV , USA.

PMID: 26779493 PMCID: PMC4700921 DOI: 10.3389/fvets.2015.00073

Abstract

OBJECTIVE: To quantitate key parameters of the platelet-rich plasma (PRP) product from five commercial canine PRP systems in healthy, adult canines.

MATERIALS AND METHODS: A prospective study was performed from January 2013 to April 2014. Five commercial systems were analyzed using 10 healthy dogs per system.(-) Blood was obtained according to the manufacturer's protocol for each system. The mean baseline whole blood platelet, RBC, WBC, neutrophil, monocyte, and lymphocyte concentrations were determined for each PRP system. All blood samples were processed according to the manufacturer's protocols. The mean PRP product platelet, RBC, WBC, neutrophil, monocyte, and lymphocyte concentrations were determined for each PRP system. These values were then compared to the mean baseline values. Comparisons of mean whole blood and mean PRP product parameters were calculated using a paired t-test with significance established at p = 0.05.

RESULTS: Platelet concentration was significantly increased for System 1 (p = 0.0088) and System 3 (p < 0.0001), and was significantly decreased for System 2 (p < 0.0001). All five systems significantly decreased the red blood cell concentration (p < 0.0001 for each system comparison). Neutrophil concentration was significantly decreased for System 2, System 3, and System 4 (p < 0.0001 for each system comparison). Neutrophil concentration was significantly increased for System 5 (p = 0.0089).

CLINICAL RELEVANCE: The systems with the highest platelet yield were System 1 and System 3. System 3 increased platelet concentration while significantly reducing the RBC and neutrophil concentrations. Further study is indicated to assess the efficacy of PRP therapy in canines, the efficacy of canine PRP systems, and the clinical applications for PRP therapy in dogs.

Keywords: autologous conditioned plasma; leukocyte-poor platelet-rich plasma; leukocyte-rich platelet-rich plasma; platelet count; platelet-rich plasma

References

  1. Am J Sports Med. 2011 Feb;39(2):266-71 - PubMed
  2. Arthroscopy. 2013 Dec;29(12):2037-48 - PubMed
  3. Vet Comp Orthop Traumatol. 2012;25(6):445-52 - PubMed
  4. Trends Biotechnol. 2009 Mar;27(3):158-67 - PubMed
  5. J Surg Res. 2013 Mar;180(1):80-8 - PubMed
  6. Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):472-9 - PubMed
  7. Biomaterials. 2012 Oct;33(29):7008-18 - PubMed
  8. J Bone Joint Surg Am. 2012 Oct 3;94(19):e143(1-8) - PubMed
  9. Sports Med Arthrosc. 2013 Dec;21(4):213-9 - PubMed
  10. Can Vet J. 2013 Sep;54(9):881-4 - PubMed
  11. Vet Comp Orthop Traumatol. 2013;26(4):285-90 - PubMed
  12. Platelets. 2008 Jun;19(4):268-74 - PubMed
  13. Knee Surg Sports Traumatol Arthrosc. 2015 Sep;23(9):2459-74 - PubMed
  14. Am J Sports Med. 2013 Feb;41(2):356-64 - PubMed
  15. Int J Sports Med. 2013 Jan;34(1):74-80 - PubMed
  16. Am J Sports Med. 2011 Oct;39(10):2135-40 - PubMed
  17. Am J Sports Med. 2012 Jun;40(6):1274-81 - PubMed
  18. Am J Sports Med. 2014 May;42(5):1204-10 - PubMed
  19. Am J Sports Med. 2014 Jan;42(1):35-41 - PubMed
  20. PLoS One. 2014 Jan 20;9(1):e85917 - PubMed
  21. BMC Musculoskelet Disord. 2012 Nov 23;13:229 - PubMed
  22. Am J Sports Med. 2011 Nov;39(11):2362-70 - PubMed
  23. Cells Tissues Organs. 2009;189(5):317-26 - PubMed
  24. Korean J Lab Med. 2011 Jul;31(3):212-8 - PubMed
  25. Eur Surg Res. 2013;51(3-4):138-45 - PubMed
  26. Vet Comp Orthop Traumatol. 2011;24(2):122-5 - PubMed
  27. Am J Sports Med. 2006 Nov;34(11):1774-8 - PubMed
  28. Pain Res Treat. 2013;2013:165967 - PubMed
  29. Arthroscopy. 2012 Mar;28(3):429-39 - PubMed
  30. J Am Acad Orthop Surg. 2013 Dec;21(12):739-48 - PubMed
  31. Tissue Eng Part C Methods. 2009 Sep;15(3):431-5 - PubMed
  32. Eur J Orthop Surg Traumatol. 2013 Jul;23(5):573-80 - PubMed
  33. Arthroscopy. 2011 Nov;27(11):1490-501 - PubMed
  34. Am J Vet Res. 2015 Sep;76(9):822-7 - PubMed
  35. Arch Oral Biol. 2010 Mar;55(3):185-94 - PubMed
  36. Curr Rev Musculoskelet Med. 2008 Dec;1(3-4):165-74 - PubMed
  37. J Bone Joint Surg Am. 2014 Mar 5;96(5):423-9 - PubMed
  38. J Orthop Res. 2009 Aug;27(8):1033-42 - PubMed
  39. J Orthop Res. 2009 Oct;27(10 ):1392-8 - PubMed
  40. Am J Sports Med. 2014 Jan;42(1):42-9 - PubMed
  41. Vet Res Commun. 2008 Sep;32 Suppl 1:S51-5 - PubMed
  42. Am J Sports Med. 2014 Mar;42(3):610-8 - PubMed
  43. J Orthop Res. 2013 Jan;31(1):29-34 - PubMed
  44. J Shoulder Elbow Surg. 2011 Jun;20(4):518-28 - PubMed
  45. Vet Comp Orthop Traumatol. 2006;19(1):43-7 - PubMed
  46. Int Orthop. 2011 Oct;35(10 ):1569-76 - PubMed
  47. Knee Surg Sports Traumatol Arthrosc. 2011 Apr;19(4):528-35 - PubMed

Publication Types