Display options
Cite
Sim J, Ahn H, Abdul R, et al. High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer. J Breast Cancer. 2015;18(4):323-8doi: 10.4048/jbc.2015.18.4.323.
Sim, J., Ahn, H., Abdul, R., Kim, H., Yi, K. J., Chung, Y. M., Chung, M. S., Paik, S. S., Song, Y. S., & Jang, K. (2015). High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer. Journal of breast cancer, 18(4), 323-8. https://doi.org/10.4048/jbc.2015.18.4.323
Sim, Jongmin, et al. "High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer." Journal of breast cancer vol. 18,4 (2015): 323-8. doi: https://doi.org/10.4048/jbc.2015.18.4.323
Sim J, Ahn H, Abdul R, Kim H, Yi KJ, Chung YM, Chung MS, Paik SS, Song YS, Jang K. High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer. J Breast Cancer. 2015 Dec;18(4):323-8. doi: 10.4048/jbc.2015.18.4.323. Epub 2015 Dec 23. PMID: 26770238; PMCID: PMC4705083.
Copy Download .nbib Format: NLM
Share it on

J Breast Cancer. 2015 Dec;18(4):323-8. doi: 10.4048/jbc.2015.18.4.323. Epub 2015 Dec 23.

High MicroRNA-370 Expression Correlates with Tumor Progression and Poor Prognosis in Breast Cancer.

Journal of breast cancer

Jongmin Sim, Hyein Ahn, Rehman Abdul, Hyunsung Kim, Ki-Jong Yi, Yu-Min Chung, Min Sung Chung, Seung Sam Paik, Young Soo Song, Kiseok Jang

Affiliations

  1. Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.
  2. Department of Surgery, Hanyang University College of Medicine, Seoul, Korea.

PMID: 26770238 PMCID: PMC4705083 DOI: 10.4048/jbc.2015.18.4.323

Abstract

PURPOSE: Deregulation of microRNA-370 (miR-370) has been reported in various cancers, in which it can act as either an oncogene or a tumor suppressor gene. However, the clinicopathologic significance of miR-370 expression in breast cancer has not been studied.

METHODS: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues. Additionally, the protein expression levels of previously known targets of miR-370, such as FOXM1, FOXO1, and FOXO3a, were detected using immunohistochemistry. Finally, we analyzed its correlation with target protein expression, clinicopathologic features, and clinical outcome.

RESULTS: High levels of miR-370 expression correlated with lymph node metastasis (p=0.009), advanced stage (p=0.002), and frequent perineural invasion (p=0.042). Moreover, patients with high miR-370 expression had poor disease-free survival compared with the low-expression group. However, no correlation was observed between miR-370 and its target protein expression.

CONCLUSION: Our results indicate that upregulation of miR-370 in breast cancer is correlated with breast cancer progression and that it might be a potential biomarker for predicting clinical outcomes.

Keywords: Breast neoplasms; MicroRNA-370; Prognosis; Real-time polymerase chain reaction

References

  1. Med Sci Monit. 2012 Aug;18(8):BR299-308 - PubMed
  2. Mol Cancer. 2012 Aug 17;11:56 - PubMed
  3. Mol Cancer Res. 2013 Aug;11(8):834-44 - PubMed
  4. Hepatology. 2013 Dec;58(6):1977-91 - PubMed
  5. Breast Cancer Res. 2009;11(3):R27 - PubMed
  6. FEBS Lett. 2013 Mar 18;587(6):639-44 - PubMed
  7. Methods Mol Biol. 2011;724:259-67 - PubMed
  8. Oncogene. 2012 Apr 5;31(14 ):1845-58 - PubMed
  9. Biomed Pharmacother. 2013 Jul;67(6):521-6 - PubMed
  10. Genome Biol. 2007;8(10):R214 - PubMed
  11. Oncogene. 2012 Jan 12;31(2):226-37 - PubMed
  12. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13021-6 - PubMed
  13. J Transl Med. 2013 Oct 23;11:265 - PubMed
  14. PLoS One. 2012;7(9):e45825 - PubMed
  15. J Mol Diagn. 2008 Nov;10(6):513-9 - PubMed
  16. Oncogene. 2014 Jun 5;33(23):3014-23 - PubMed
  17. Cell Cycle. 2007 Sep 1;6(17):2127-32 - PubMed
  18. PLoS One. 2011;6(6):e20980 - PubMed
  19. Cancer Res. 2005 Aug 15;65(16):7065-70 - PubMed
  20. Cell. 2009 Jan 23;136(2):215-33 - PubMed
  21. Br J Cancer. 2012 Aug 7;107(4):684-94 - PubMed
  22. BMC Biotechnol. 2007 Jun 29;7:36 - PubMed
  23. PLoS One. 2012;7(10):e47717 - PubMed
  24. Biomed Pharmacother. 2014 Mar;68(2):149-54 - PubMed
  25. Bioinformatics. 2014 Jun 1;30(11):1630-2 - PubMed
  26. Oral Dis. 2013 Sep;19(6):611-9 - PubMed
  27. Oncol Lett. 2013 May;5(5):1605-1610 - PubMed

Publication Types