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Dhanasekaran S, Suneja A, Bisai V, et al. Approach to Isoindolinones, Isoquinolinones, and THIQs via Lewis Acid-Catalyzed Domino Strecker-Lactamization/Alkylations. Org Lett. 2016;18(4):634-7doi: 10.1021/acs.orglett.5b03331.
Dhanasekaran, S., Suneja, A., Bisai, V., & Singh, V. K. (2016). Approach to Isoindolinones, Isoquinolinones, and THIQs via Lewis Acid-Catalyzed Domino Strecker-Lactamization/Alkylations. Organic letters, 18(4), 634-7. https://doi.org/10.1021/acs.orglett.5b03331
Dhanasekaran, Sivasankaran, et al. "Approach to Isoindolinones, Isoquinolinones, and THIQs via Lewis Acid-Catalyzed Domino Strecker-Lactamization/Alkylations." Organic letters vol. 18,4 (2016): 634-7. doi: https://doi.org/10.1021/acs.orglett.5b03331
Dhanasekaran S, Suneja A, Bisai V, Singh VK. Approach to Isoindolinones, Isoquinolinones, and THIQs via Lewis Acid-Catalyzed Domino Strecker-Lactamization/Alkylations. Org Lett. 2016 Feb 19;18(4):634-7. doi: 10.1021/acs.orglett.5b03331. Epub 2016 Feb 04. PMID: 26843100.
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Org Lett. 2016 Feb 19;18(4):634-7. doi: 10.1021/acs.orglett.5b03331. Epub 2016 Feb 04.

Approach to Isoindolinones, Isoquinolinones, and THIQs via Lewis Acid-Catalyzed Domino Strecker-Lactamization/Alkylations.

Organic letters

Sivasankaran Dhanasekaran, Arun Suneja, Vishnumaya Bisai, Vinod K Singh

Affiliations

  1. Department of Chemistry, Indian Institute of Technology , Kanpur, UP - 208 016, India.
  2. Department of Chemistry, Indian Institute of Science Education and Research , Bhopal, MP - 462 066, India.

PMID: 26843100 DOI: 10.1021/acs.orglett.5b03331

Abstract

A one-pot, three-component synthesis of widely substituted isoindolinones and isoquinolinones, featuring a Lewis acid-catalyzed efficient Strecker reaction and lactamization sequence, affording products in good to high yields is reported. The method has also been extended to the synthesis of tetrahydroisoquinolines (THIQs) in high yields.

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