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Synlett. 2014 Jun;25(10):1403-1408. doi: 10.1055/s-0033-1339025.

Selective Reduction of Halogenated Nitroarenes with Hydrazine Hydrate in the Presence of Pd/C.

Synlett : accounts and rapid communications in synthetic organic chemistry

Fang Li, Brendan Frett, Hong-Yu Li

Affiliations

  1. College of Pharmacy, Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85721, USA, Fax +1(520)6260794; BIO-5 Oro Valley, The University of Arizona, 1580 E. Hanley Blvd, Oro Valley, AZ 85737, USA.

PMID: 26843785 PMCID: PMC4734645 DOI: 10.1055/s-0033-1339025

Abstract

A large variety of halogenated nitroarenes have been selectively reduced with hydrazine hydrate in the presence of Pd/C to give the corresponding (halogenated) anilines in good yield.

Keywords: aromatic amines; hydrazine hydrate; nitroarenes; palladium on carbon; reduction; transfer hydrogenation

References

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