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Diebel KW, Zhou K, Clarke AB, et al. Beyond the Ribosome: Extra-translational Functions of tRNA Fragments. Biomark Insights. 2016;11:1-8doi: 10.4137/BMI.S35904.
Diebel, K. W., Zhou, K., Clarke, A. B., & Bemis, L. T. (2016). Beyond the Ribosome: Extra-translational Functions of tRNA Fragments. Biomarker insights, 111-8. https://doi.org/10.4137/BMI.S35904
Diebel, Kevin W, et al. "Beyond the Ribosome: Extra-translational Functions of tRNA Fragments." Biomarker insights vol. 11 (2016): 1-8. doi: https://doi.org/10.4137/BMI.S35904
Diebel KW, Zhou K, Clarke AB, Bemis LT. Beyond the Ribosome: Extra-translational Functions of tRNA Fragments. Biomark Insights. 2016 Jan 28;11:1-8. doi: 10.4137/BMI.S35904. eCollection 2016. PMID: 26843810; PMCID: PMC4734663.
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Biomark Insights. 2016 Jan 28;11:1-8. doi: 10.4137/BMI.S35904. eCollection 2016.

Beyond the Ribosome: Extra-translational Functions of tRNA Fragments.

Biomarker insights

Kevin W Diebel, Kun Zhou, Aaron B Clarke, Lynne T Bemis

Affiliations

  1. Department of Biomedical Sciences, University of Minnesota Medical School Duluth campus, Duluth, MN, USA.

PMID: 26843810 PMCID: PMC4734663 DOI: 10.4137/BMI.S35904

Abstract

High-throughput sequencing studies of small RNAs reveal a complex milieu of noncoding RNAs in biological samples. Early data analysis was often limited to microRNAs due to their regulatory nature and potential as biomarkers; however, many more classes of noncoding RNAs are now being recognized. A class of fragments initially excluded from analysis were those derived from transfer RNAs (tRNAs) because they were thought to be degradation products. More recently, critical cellular function has been attributed to tRNA fragments (tRFs), and their conservation across all domains of life has propelled them into an emerging area of scientific study. The biogenesis of tRFs is currently being elucidated, and initial studies show that a diverse array of tRFs are generated from all parts of a tRNA molecule. The goal of this review was to present what is currently known about tRFs and their potential as biomarkers for the earlier detection of disease.

Keywords: angiogenin; cancer; tRFs; tRNA biomarkers; tRNA fragments

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