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von Wild K, Gerstenbrand F, Dolce G, et al. Guidelines for Quality Management of Apallic Syndrome / Vegetative State. Eur J Trauma Emerg Surg. 2007;33(3):268-92doi: 10.1007/s00068-007-6138-1.
von Wild, K., Gerstenbrand, F., Dolce, G., Binder, H., Vos, P. E., Saltuari, L., Alekseenko, Y., Formisano, R., Ritz, A., Ortega-Suhrkamp, E., Jörg, J. R., Potapov, A. A., León-Carrión, J., Vilcinis, R., & Zitnay, G. A. (2007). Guidelines for Quality Management of Apallic Syndrome / Vegetative State. European journal of trauma and emergency surgery : official publication of the European Trauma Society, 33(3), 268-92. https://doi.org/10.1007/s00068-007-6138-1
von Wild, Klaus, et al. "Guidelines for Quality Management of Apallic Syndrome / Vegetative State." European journal of trauma and emergency surgery : official publication of the European Trauma Society vol. 33,3 (2007): 268-92. doi: https://doi.org/10.1007/s00068-007-6138-1
von Wild K, Gerstenbrand F, Dolce G, Binder H, Vos PE, Saltuari L, Alekseenko Y, Formisano R, Ritz A, Ortega-Suhrkamp E, Jörg JR, Potapov AA, León-Carrión J, Vilcinis R, Zitnay GA. Guidelines for Quality Management of Apallic Syndrome / Vegetative State. Eur J Trauma Emerg Surg. 2007 Jun;33(3):268-92. doi: 10.1007/s00068-007-6138-1. Epub 2007 Apr 21. PMID: 26814491.
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Eur J Trauma Emerg Surg. 2007 Jun;33(3):268-92. doi: 10.1007/s00068-007-6138-1. Epub 2007 Apr 21.

Guidelines for Quality Management of Apallic Syndrome / Vegetative State.

European journal of trauma and emergency surgery : official publication of the European Trauma Society

Klaus von Wild, Franz Gerstenbrand, Giuliano Dolce, Heinrich Binder, Pieter E Vos, Leopold Saltuari, Yuri Alekseenko, Rita Formisano, Annegret Ritz, Erika Ortega-Suhrkamp, Johannes R Jörg, Alexander A Potapov, José León-Carrión, Rimantas Vilcinis, George A Zitnay

Affiliations

  1. Medical Faculty, W.W.-University of Muenster, Muenster, Germany. [email protected].
  2. Academic Clemenshospital, Münster, Germany. [email protected].
  3. Medical University Innsbruck, Ludwig Boltzmann Institute for Restorative Neurology and Neuromodulation, Vienna, Austria.
  4. Institute S. Anna for Intensive Care and Rehabilitation, Crotone, Italy.
  5. Zentrum "Rothschildstiftung Maria Theresien Schlössel" SMZ Baumgartner Höhe, Otto Wagner Spital, Vienna, Austria.
  6. Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
  7. Department of Neurologische Akutnachbehandlung, Ö. Landeskrankenhaus Hochzirl, Anna Dengel Haus, Zirl, Austria.
  8. Department of Neurology and Neurosurgery, Vitebsk Medical University, Vitebsk, Belarus.
  9. Unità Post-Coma, Ospedale di Riabilitazione Fondazione Santa Lucia, Rome, Italy.
  10. Neurological Rehabilitation, Centre for children Friedehorst, Bremen, Germany.
  11. Schlossberg Klinik for Early Neurological Rehabilitation, Bad König, Germany.
  12. Neurology and Clinical neurophysiology, Klinikum Helios, University Witten, Wuppertal, Germany.
  13. The Burdenko Neurosurgery Institute, Moscow, Russia.
  14. Centro de Rehabilitation de Dano Cerebral CRECER Sevilla, Sevilla, Spain.
  15. Department of Head Injuries, Medical University Hospital, Kaunas, Lithunia.
  16. Defence and Veterans Brain Injury Centre and National Brain Injury Research, and Treatment Teaching Foundation, Charlottesville, VA, USA.

PMID: 26814491 DOI: 10.1007/s00068-007-6138-1

Abstract

INTRODUCTION: Epidemiology in Europe shows constantly increasing figures for the apallic syndrome (AS)/vegetative state (VS) as a consequence of advanced rescue, emergency services, intensive care treatment after acute brain damage and high-standard activating home nursing for completely dependent end-stage cases secondary to progressive neurological disease. Management of patients in irreversible permanent AS/VS has been the subject of sustained scientific and moral-legal debate over the past decade.

METHODS: A task force on guidelines for quality management of AS/VS was set up under the auspices of the Scientific Panel Neurotraumatology of the European Federation of Neurological Societies to address key issues relating to AS/VS prevalence and quality management. Collection and analysis of scientific data on class II (III) evidence from the literature and recommendations based on the best practice as resulting from the task force members' expertise are in accordance with EFNS Guidance regulations.

FINDINGS: The overall incidence of new AS/VS full stage cases all etiology is 0.5-2/100.000 population per year. About one third are traumatic and two thirds non traumatic cases. Increasing figures for hypoxic brain damage and progressive neurological disease have been noticed. The main conceptual criticism is based on the assessment and diagnosis of all different AS/VS stages based solely on behavioural findings without knowing the exact or uniform pathogenesis or neuropathological findings and the uncertainty of clinical assessment due to varying inclusion criteria. No special diagnostics, no specific medical management can be recommended for class II or III AS treatment and rehabilitation. This is why sine qua non diagnostics of the clinical features and appropriate treatment of AS/VS patients of "AS full, remission, defect and end stages" require further professional training and expertise for doctors and rehabilitation personnel.

INTERPRETATION: Management of AS aims at the social reintegration of patients or has to guarantee humanistic active nursing if treatment fails. Outcome depends on the cause and duration of AS/VS as well as patient's age. There is no single AS/VS specific laboratory investigation, no specific regimen or stimulating intervention to be recommended for improving higher cerebral functioning. Quality management requires at least 3 years of advanced training and permanent education to gain approval of qualification for AS/VS treatment and expertise. Sine qua non areas covering AS/VS institutions for early and long-term rehabilitation are required on a population base (prevalence of 2/100.000/year) to quicken functional restoration and to prevent or treat complications. Caring homes are needed for respectful humane nursing including basal sensor-motor stimulating techniques. Passive euthanasia is considered an act of mercy by physicians in terms of withholding treatment; however, ethical and legal issues with regard to withdrawal of nutrition and hydration and end of life discussions raise deep concerns. The aim of the guideline is to provide management guidance (on the best medical evidence class II and III or task force expertise) for neurologists, neurosurgeons, other physicians working with AS/VS patients, neurorehabilitation personnel, patients, next-of-kin, and health authorities.

Keywords: Apallic syndrome; Evidence-based medicine; Functional assessment; Management guideline; Multidisciplinary neurotraumatology; Neurorehabilitation; Outcome following severe brain damage; Vegetative state; Withdrawal of nutrition and hydration

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