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Wei H, Wang CE, Tan N, et al. ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators. ACS Macro Lett. 2015;4(9):938-941doi: 10.1021/acsmacrolett.5b00565.
Wei, H., Wang, C. E., Tan, N., Boydston, A. J., & Pun, S. H. (2015). ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators. ACS macro letters, 4(9), 938-941. https://doi.org/10.1021/acsmacrolett.5b00565
Wei, Hua, et al. "ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators." ACS macro letters vol. 4,9 (2015): 938-941. doi: https://doi.org/10.1021/acsmacrolett.5b00565
Wei H, Wang CE, Tan N, Boydston AJ, Pun SH. ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators. ACS Macro Lett. 2015 Sep 15;4(9):938-941. doi: 10.1021/acsmacrolett.5b00565. Epub 2015 Aug 17. PMID: 26900511; PMCID: PMC4755328.
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ACS Macro Lett. 2015 Sep 15;4(9):938-941. doi: 10.1021/acsmacrolett.5b00565. Epub 2015 Aug 17.

ATRP Synthesis of Sunflower Polymers using Cyclic Multimacroinitiators.

ACS macro letters

Hua Wei, Christine E Wang, Nicholas Tan, Andrew J Boydston, Suzie H Pun

Affiliations

  1. Department of Bioengineering and Molecular Engineering & Sciences Institute, University of Washington, Seattle, Washington 98195, United States.
  2. Department of Chemistry University of Washington, Seattle, Washington 98195, United States.

PMID: 26900511 PMCID: PMC4755328 DOI: 10.1021/acsmacrolett.5b00565

Abstract

Polymers with advanced architectures can now be readily and reproducibly synthesized using controlled living polymerization. These materials are attractive as potential drug carriers due to their tunable size, versatile methods of drug incorporation and release, and ease of functionalization with targeting ligands. In this work, we report the design and development of macrocyclic brush, or "sunflower," polymers, synthesized by controlled radical polymerization of hydrophilic "petals" from a cyclic multimacroinitiator "core." These nanostructures can be synthesized with low polydispersity and controlled sizes depending on polymerization time. We further demonstrate that folate-functionalized sunflower polymers facilitate receptor-mediated uptake into cancer cells. These materials therefore show potential as drug carriers for anti-cancer therapies.

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