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Lin D, Rein L, Tarima S, et al. The Relationship between Metformin and Obstructive Sleep Apnea. J Sleep Med Disord. 2015;2(4)
Lin, D., Rein, L., Tarima, S., Woodson, B. T., & Meurer, J. R. (2015). The Relationship between Metformin and Obstructive Sleep Apnea. Journal of sleep medicine and disorders, 2(4), .
Lin, Deborah, et al. "The Relationship between Metformin and Obstructive Sleep Apnea." Journal of sleep medicine and disorders vol. 2,4 (2015).
Lin D, Rein L, Tarima S, Woodson BT, Meurer JR. The Relationship between Metformin and Obstructive Sleep Apnea. J Sleep Med Disord. 2015;2(4). Epub 2015 Aug 07. PMID: 26900606; PMCID: PMC4756758.
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J Sleep Med Disord. 2015;2(4). Epub 2015 Aug 07.

The Relationship between Metformin and Obstructive Sleep Apnea.

Journal of sleep medicine and disorders

Deborah Lin, Lisa Rein, Sergey Tarima, B Tucker Woodson, John R Meurer

Affiliations

  1. Clinical and Translational Science Institute, Medical College of Wisconsin (MCW), USA.
  2. Division of Biostatistics, Institute for Health and Society, USA.
  3. Department of Otolaryngology, MCW, USA.
  4. Division of Population Health Improvement, Institute for Health and Society, USA.

PMID: 26900606 PMCID: PMC4756758

Abstract

OBJECTIVES: This study aimed to assess if metformin had any associations with the prevalence of obstructive sleep apnea in an adult type 2 diabetes population in the Midwest.

HYPOTHESIS: Use of metformin is associated with decreased prevalence of obstructive sleep apnea in a adult type 2 diabetes population.

METHODS: A retrospective secondary database analysis was carried out with metformin use by patients with type 2 diabetes as the primary variable of interest and obstructive sleep apnea status as the primary outcome. A sample population of 9,853 type 2 diabetes patients with one year of follow-up was used. Other variables that were analyzed included age, gender, race, hypertension, Congestive Heart Failure, Hemoglobin A1c (HbA1c), and Body Mass Index. A p-value of <0.01 was considered significant.

RESULTS: Metformin usage was not significantly associated with obstructive sleep apnea prevalence (Odds Ratio: 1.17, Confidence Interval: 1.00-1.36, p = 0.049), but trended in the direction where metformin usage was associated with having obstructive sleep apnea. Lower HbA1c was found to be significantly associated with lower prevalence of obstructive sleep apnea (p <0.001). The rest of the variables followed previously published associations.

CONCLUSIONS: Metformin therapy may improve sleep quality, but it may not be through methods that reduce the likelihood of developing obstructive sleep apnea. Future studies that can prove causation about this association should be considered.

Keywords: Insulin resistance; Metformin; Obstructive sleep apnea; Type 2 diabetes

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