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Franchello A, Fronda G, Deiro G, et al. Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery. Case Rep Surg. 2015;2015:256838doi: 10.1155/2015/256838.
Franchello, A., Fronda, G., Deiro, G., Fiore, A., Cassine, D., Molinaro, L., Chiusa, L., Galati, S., Resegotti, A., & Silvestri, S. (2015). Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery. Case reports in surgery, 2015256838. https://doi.org/10.1155/2015/256838
Franchello, Alessandro, et al. "Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery." Case reports in surgery vol. 2015 (2015): 256838. doi: https://doi.org/10.1155/2015/256838
Franchello A, Fronda G, Deiro G, Fiore A, Cassine D, Molinaro L, Chiusa L, Galati S, Resegotti A, Silvestri S. Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery. Case Rep Surg. 2015;2015:256838. doi: 10.1155/2015/256838. Epub 2015 Dec 09. PMID: 26783488; PMCID: PMC4689907.
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Case Rep Surg. 2015;2015:256838. doi: 10.1155/2015/256838. Epub 2015 Dec 09.

Unusual Presentation of Recurrent Early Stage Endometrial Carcinoma 28 Years after Primary Surgery.

Case reports in surgery

Alessandro Franchello, Gianruggero Fronda, Giacomo Deiro, Alessia Fiore, Davide Cassine, Luca Molinaro, Luigi Chiusa, Sara Galati, Andrea Resegotti, Stefano Silvestri

Affiliations

  1. 4th General Surgery Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.
  2. 2nd Phathological Anatomy Department, Azienda Ospedaliera Universitaria Città della Salute e della Scienza, 10126 Turin, Italy.

PMID: 26783488 PMCID: PMC4689907 DOI: 10.1155/2015/256838

Abstract

Endometrial carcinoma is the most common neoplasia of female genital tract. The prognosis of early stage disease (FIGO I and FIGO II) is excellent: recurrence after surgery is less than 15%, most of which are reported within 3 years after primary treatment. Herein we report a case of late rectal recurrence from FIGO Ib endometrial adenocarcinoma. Patient had also familiar and personal history of colonic adenocarcinoma and previous findings of microsatellite instability (MSI); molecular analysis evidenced heterozygotic somatic mutation in MLH1 gene. Twenty-eight years after hysterectomy and bilateral salpingoovariectomy, a rectal wall mass was detected during routine colonoscopy. Patients underwent CT scan, pelvic MRI, and rectal EUS with FNA: histopathological and immunohistochemical analysis revealed differentiated carcinoma cells of endometrial origin. No neoadjuvant treatment was planned and low rectal anterior resection with protective colostomy was performed; histology confirmed rectal lesion as metastasis from endometrial carcinoma. Recurrence of early stage endometrial carcinoma after a long period from primary surgery is possible. It is important to keep in mind this possibility in order to set a correct diagnostic and therapeutic algorithm, including preoperative immunohistochemical staining, and to plan a prolonged follow-up program.

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