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Punet X, Mauchauffé R, Rodríguez-Cabello JC, et al. Biomolecular functionalization for enhanced cell-material interactions of poly(methyl methacrylate) surfaces. Regen Biomater. 2015;2(3):167-75doi: 10.1093/rb/rbv014.
Punet, X., Mauchauffé, R., Rodríguez-Cabello, J. C., Alonso, M., Engel, E., & Mateos-Timoneda, M. A. (2015). Biomolecular functionalization for enhanced cell-material interactions of poly(methyl methacrylate) surfaces. Regenerative biomaterials, 2(3), 167-75. https://doi.org/10.1093/rb/rbv014
Punet, Xavier, et al. "Biomolecular functionalization for enhanced cell-material interactions of poly(methyl methacrylate) surfaces." Regenerative biomaterials vol. 2,3 (2015): 167-75. doi: https://doi.org/10.1093/rb/rbv014
Punet X, Mauchauffé R, Rodríguez-Cabello JC, Alonso M, Engel E, Mateos-Timoneda MA. Biomolecular functionalization for enhanced cell-material interactions of poly(methyl methacrylate) surfaces. Regen Biomater. 2015 Sep;2(3):167-75. doi: 10.1093/rb/rbv014. Epub 2015 Aug 07. PMID: 26816640; PMCID: PMC4669015.
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Regen Biomater. 2015 Sep;2(3):167-75. doi: 10.1093/rb/rbv014. Epub 2015 Aug 07.

Biomolecular functionalization for enhanced cell-material interactions of poly(methyl methacrylate) surfaces.

Regenerative biomaterials

Xavier Punet, Rodolphe Mauchauffé, José C Rodríguez-Cabello, Matilde Alonso, Elisabeth Engel, Miguel A Mateos-Timoneda

Affiliations

  1. Biomaterials for Regenerative Therapies Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona 08028, Spain,; CIBER en Bioingenería, Biomateriales y Nanomedicina (CIBER-BBN), Spain.
  2. Biomaterials for Regenerative Therapies Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona 08028, Spain.
  3. CIBER en Bioingenería, Biomateriales y Nanomedicina (CIBER-BBN), Spain,; G.I.R. Bioforge, Universidad Valladolid (UVA), Valladolid 47011, Spain and.
  4. Biomaterials for Regenerative Therapies Group, Institute for Bioengineering of Catalonia (IBEC), Barcelona 08028, Spain,; CIBER en Bioingenería, Biomateriales y Nanomedicina (CIBER-BBN), Spain,; Department of Material Science and Metallurgical Engineering, Technical University of Catalonia (UPC), Barcelona 08028, Spain.

PMID: 26816640 PMCID: PMC4669015 DOI: 10.1093/rb/rbv014

Abstract

The integration of implants or medical devices into the body tissues requires of good cell-material interactions. However, most polymeric materials used for these applications lack on biological cues, which enhanced mid- and long-term implant failure due to weak integration with the surrounding tissue. Commonly used strategies for tissue-material integration focus on functionalization of the material surface by means of natural proteins or short peptides. However, the use of these biomolecules involves major drawbacks such as immunogenic problems and oversimplification of the constructs. Here, designed elastin-like recombinamers (ELRs) are used to enhance poly(methyl methacrylate) surface properties and compared against the use of short peptides. In this study, cell response has been analysed for different functionalization conditions in the presence and absence of a competing protein, which interferes on surface-cell interaction by unspecific adsorption on the interface. The study has shown that ELRs can induce higher rates of cell attachment and stronger cell anchorages than short peptides, being a better choice for surface functionalization.

Keywords: PMMA; RGD peptide; cell adhesion; elastin-like recombinamer; poly(methyl methacrylate); surface modification

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