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Varela-López A, Quiles JL, Cordero M, et al. Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease. Antioxidants (Basel). 2015;4(2):322-44doi: 10.3390/antiox4020322.
Varela-López, A., Quiles, J. L., Cordero, M., Giampieri, F., & Bullón, P. (2015). Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease. Antioxidants (Basel, Switzerland), 4(2), 322-44. https://doi.org/10.3390/antiox4020322
Varela-López, Alfonso, et al. "Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease." Antioxidants (Basel, Switzerland) vol. 4,2 (2015): 322-44. doi: https://doi.org/10.3390/antiox4020322
Varela-López A, Quiles JL, Cordero M, Giampieri F, Bullón P. Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease. Antioxidants (Basel). 2015 Apr 28;4(2):322-44. doi: 10.3390/antiox4020322. PMID: 26783708; PMCID: PMC4665476.
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Antioxidants (Basel). 2015 Apr 28;4(2):322-44. doi: 10.3390/antiox4020322.

Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease.

Antioxidants (Basel, Switzerland)

Alfonso Varela-López, José L Quiles, Mario Cordero, Francesca Giampieri, Pedro Bullón

Affiliations

  1. Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Center (CIBM), University of Granada, Avda. del Conocimiento s.n., Armilla, Granada 18100, Spain. [email protected].
  2. Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Center (CIBM), University of Granada, Avda. del Conocimiento s.n., Armilla, Granada 18100, Spain. [email protected].
  3. Department of Periodontology, Dental School, University of Sevilla, C/Avicena s.n., Sevilla 41009, Spain. [email protected].
  4. Department of Clinical Sciences, Marche Polytechnic University, Ancona 60100, Italy. [email protected].
  5. Department of Periodontology, Dental School, University of Sevilla, C/Avicena s.n., Sevilla 41009, Spain. [email protected].

PMID: 26783708 PMCID: PMC4665476 DOI: 10.3390/antiox4020322

Abstract

Oxidative stress is one of the main factors studied to explain the pathophysiological mechanisms of inflammatory conditions, such as periodontitis. In this respect, nutrition may be of great importance. Actually, research on nutrients' effects on periodontal diseases has expanded to include those influencing the redox status, which correlates to the inflammatory process. Dietary fat or lipids are often blamed as the major source of excess energy. Consequently, when caloric intake exceeds energy expenditure, the resultant substrate-induced increase in citric acid cycle activity generates an excess of reactive oxygen species (ROS). In addition, dietary fatty acid intake influences in relative fatty acid composition of biological membranes determining its susceptibility to oxidative alterations. From this standpoint, here, we reviewed studies analyzing the dietary fat role in periodontal disease. Research data suggest that periodontal health could be achieved by main dietary strategies which include substitution of saturated fats with monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA), particularly n-3 PUFA. Maybe in the future, we should analyze the diet and provide some advice to periodontitis patients to improve treatment outcomes.

Keywords: cholesterol; diet; dietary fats; fatty acids; lipids; nutrition; periodontitis

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