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George M, Ganesh MR, Sridhar A, et al. Evaluation of Endothelial and Platelet Derived Microparticles in Patients with Acute Coronary Syndrome. J Clin Diagn Res. 2015;9(12):OC09-13doi: 10.7860/JCDR/2015/14493.6920.
George, M., Ganesh, M. R., Sridhar, A., Jena, A., Rajaram, M., Shanmugam, E., & Dhandapani, V. E. (2015). Evaluation of Endothelial and Platelet Derived Microparticles in Patients with Acute Coronary Syndrome. Journal of clinical and diagnostic research : JCDR, 9(12), OC09-13. https://doi.org/10.7860/JCDR/2015/14493.6920
George, Melvin, et al. "Evaluation of Endothelial and Platelet Derived Microparticles in Patients with Acute Coronary Syndrome." Journal of clinical and diagnostic research : JCDR vol. 9,12 (2015): OC09-13. doi: https://doi.org/10.7860/JCDR/2015/14493.6920
George M, Ganesh MR, Sridhar A, Jena A, Rajaram M, Shanmugam E, Dhandapani VE. Evaluation of Endothelial and Platelet Derived Microparticles in Patients with Acute Coronary Syndrome. J Clin Diagn Res. 2015 Dec;9(12):OC09-13. doi: 10.7860/JCDR/2015/14493.6920. Epub 2015 Dec 01. PMID: 26816931; PMCID: PMC4717789.
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J Clin Diagn Res. 2015 Dec;9(12):OC09-13. doi: 10.7860/JCDR/2015/14493.6920. Epub 2015 Dec 01.

Evaluation of Endothelial and Platelet Derived Microparticles in Patients with Acute Coronary Syndrome.

Journal of clinical and diagnostic research : JCDR

Melvin George, M R Ganesh, Aruna Sridhar, Amrita Jena, Muthukumar Rajaram, Elangovan Shanmugam, V E Dhandapani

Affiliations

  1. Assistant Professor, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
  2. Assistant Professor, Interdisciplinary School of Indian System of Medicine, SRM University , Tamil Nadu, India .
  3. Clinical Research Associate, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
  4. Professor, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .
  5. HOD and Professor, Department of Cardiology, SRM Medical College Hospital & Research Centre , Tamil Nadu, India .

PMID: 26816931 PMCID: PMC4717789 DOI: 10.7860/JCDR/2015/14493.6920

Abstract

BACKGROUND: Microparticles (MP) are a nuclear fragments of membrane released by the damaged cell during stress. Elevated levels of MP have been found in patients with acute coronary syndrome (ACS) owing to the damage in the endothelium.

AIM: To determine if the levels of endothelial and platelet microparticles (EMP & PMP) in patients with ACS influenced the severity of the disease.

MATERIALS AND METHODS: This was a prospective cohort study performed in 63 ACS patients (ST elevation myocardial infarction- STEMI-28, non ST elevation myocardial infarction -NSTEMI-35). After obtaining consent, blood samples were collected from the patients and processed by flow cytometry.

RESULTS: The NSTEMI group had higher levels of EMP {792.11(327.59-1661.49) vs 300.35 (176.3-550.46), p=0.001} and PMP {218.87(86.65-439.77) vs 114.45(50.34-196.75), p= 0.007} as compared to the STEMI group. However, it was found that the EMP (r=-0.438, p=0.001) and PMP (r= -0.316, p=0.024) negatively correlated with Global Registry of Acute Coronary Events score (GRACE in-hospital score) for the entire cohort.

CONCLUSION: The levels of microparticles are elevated in ACS patients and may reflect a protective effect in patients with acute coronary syndrome.

Keywords: Endothelial microparticles; GRACE Score; Myocardial infarction; Platelet microparticles

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